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Benzolamide

🥰Excellent
Catalog No. T23782Cas No. 3368-13-6
Alias W-1803, W 1803, CL-11366, CL11366, CL 11366

Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.

Benzolamide

Benzolamide

🥰Excellent
Purity: 99.31%
Catalog No. T23782Alias W-1803, W 1803, CL-11366, CL11366, CL 11366Cas No. 3368-13-6
Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$47In StockIn Stock
10 mg$80In StockIn Stock
25 mg$163In StockIn Stock
50 mg$247In StockIn Stock
100 mg$368In StockIn Stock
200 mg$543In StockIn Stock
1 mL x 10 mM (in DMSO)$52In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.31%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.
Targets&IC50
VchCAγ:78 nM (Ki), CAS3:54 nM (Ki), CA II (human):9 nM (Ki), CA (human):15 nM (Ki), EcoCAγ:94 nM (Ki)
In vitro
Benzolamide inhibits hCA I, hCA II, EcoCAγ and VchCAγ, with Kis of 15 nM, 9 nM, 94 nM and 78 nM, respectively[1]. Benzolamide shows selectivity for CAS3 with a Ki of 54 nM over CAS1 with a Ki of 2115 nM and CAS2 with a Ki of 410 nM[2].
In vivo
Administration of 90 μmol/kg Benzolamide decreases brain pH and suppresses electrographic post-asphyxia seizures in rats[3].
SynonymsW-1803, W 1803, CL-11366, CL11366, CL 11366
Chemical Properties
Molecular Weight320.37
FormulaC8H8N4O4S3
Cas No.3368-13-6
SmilesNS(=O)(=O)c1nnc(NS(=O)(=O)c2ccccc2)s1
Relative Density.1.746g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 250 mg/mL (780.35 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (15.61 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1214 mL15.6070 mL31.2139 mL156.0695 mL
5 mM0.6243 mL3.1214 mL6.2428 mL31.2139 mL
10 mM0.3121 mL1.5607 mL3.1214 mL15.6070 mL
20 mM0.1561 mL0.7803 mL1.5607 mL7.8035 mL
50 mM0.0624 mL0.3121 mL0.6243 mL3.1214 mL
100 mM0.0312 mL0.1561 mL0.3121 mL1.5607 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

W1803seizuresInhibitorinhibitglaucomaCAS3CarbonicAnhydrasecarbonic anhydraseCarbonic AnhydraseCarbonate dehydrataseBenzolamide
Related Tags: buy Benzolamide | purchase Benzolamide | Benzolamide cost | order Benzolamide | Benzolamide chemical structure | Benzolamide in vivo | Benzolamide in vitro | Benzolamide formula | Benzolamide molecular weight
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