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Benzolamide

Name: Benzolamide
Brand: TargetMol
SKU: T23782
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23782Cas No. 3368-13-6

Alias W-1803, W 1803, CL-11366, CL11366, CL 11366

Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.

Benzolamide

🥰Excellent

Purity: 99.31%

Catalog No. T23782Alias W-1803, W 1803, CL-11366, CL11366, CL 11366Cas No. 3368-13-6

Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.

Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$80	In Stock
25 mg	$163	In Stock
50 mg	$247	In Stock
100 mg	$368	In Stock
200 mg	$543	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock

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Purity:99.31%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.
Targets&IC50	VchCAγ:78 nM (Ki), CAS3:54 nM (Ki), CA II (human):9 nM (Ki), CA (human):15 nM (Ki), EcoCAγ:94 nM (Ki)
In vitro	Benzolamide inhibits hCA I, hCA II, EcoCAγ and VchCAγ, with Kis of 15 nM, 9 nM, 94 nM and 78 nM, respectively[1]. Benzolamide shows selectivity for CAS3 with a Ki of 54 nM over CAS1 with a Ki of 2115 nM and CAS2 with a Ki of 410 nM[2].
In vivo	Administration of 90 μmol/kg Benzolamide decreases brain pH and suppresses electrographic post-asphyxia seizures in rats[3].
Synonyms	W-1803, W 1803, CL-11366, CL11366, CL 11366

Chemical Properties

Molecular Weight	320.37
Formula	C₈H₈N₄O₄S₃
Cas No.	3368-13-6
Smiles	NS(=O)(=O)c1nnc(NS(=O)(=O)c2ccccc2)s1
Relative Density.	1.746g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (780.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1214 mL	15.6070 mL	31.2139 mL	156.0695 mL
5 mM	0.6243 mL	3.1214 mL	6.2428 mL	31.2139 mL
10 mM	0.3121 mL	1.5607 mL	3.1214 mL	15.6070 mL
20 mM	0.1561 mL	0.7803 mL	1.5607 mL	7.8035 mL
50 mM	0.0624 mL	0.3121 mL	0.6243 mL	3.1214 mL
100 mM	0.0312 mL	0.1561 mL	0.3121 mL	1.5607 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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