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Benzolamide

Name: Benzolamide
Brand: TargetMol
SKU: T23782
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T23782Cas No. 3368-13-6

Alias W-1803, W 1803, CL-11366, CL11366, CL 11366

Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.

Benzolamide

🥰Excellent

Purity: 99.31%

Catalog No. T23782Alias W-1803, W 1803, CL-11366, CL11366, CL 11366Cas No. 3368-13-6

Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$47	In Stock	In Stock
10 mg	$80	In Stock	In Stock
25 mg	$163	In Stock	In Stock
50 mg	$247	In Stock	In Stock
100 mg	$368	In Stock	In Stock
200 mg	$543	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.31%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.
Targets&IC50	VchCAγ:78 nM (Ki), CA (human):15 nM (Ki), CA II (human):9 nM (Ki), CAS3:54 nM (Ki), EcoCAγ:94 nM (Ki)
In vitro	Benzolamide inhibits hCA I, hCA II, EcoCAγ and VchCAγ, with Kis of 15 nM, 9 nM, 94 nM and 78 nM, respectively[1]. Benzolamide shows selectivity for CAS3 with a Ki of 54 nM over CAS1 with a Ki of 2115 nM and CAS2 with a Ki of 410 nM[2].
In vivo	Administration of 90 μmol/kg Benzolamide decreases brain pH and suppresses electrographic post-asphyxia seizures in rats[3].
Synonyms	W-1803, W 1803, CL-11366, CL11366, CL 11366

Chemical Properties

Molecular Weight	320.37
Formula	C₈H₈N₄O₄S₃
Cas No.	3368-13-6
Smiles	NS(=O)(=O)c1nnc(NS(=O)(=O)c2ccccc2)s1
Relative Density.	1.746g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (780.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (15.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1214 mL	15.6070 mL	31.2139 mL	156.0695 mL
5 mM	0.6243 mL	3.1214 mL	6.2428 mL	31.2139 mL
10 mM	0.3121 mL	1.5607 mL	3.1214 mL	15.6070 mL
20 mM	0.1561 mL	0.7803 mL	1.5607 mL	7.8035 mL
50 mM	0.0624 mL	0.3121 mL	0.6243 mL	3.1214 mL
100 mM	0.0312 mL	0.1561 mL	0.3121 mL	1.5607 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc