Shopping Cart
Remove All
Your shopping cart is currently empty
L-Methionine
Copy Product Info
😃Good
Catalog No. T4844Cas No. 63-68-3
Alias L-Methionin, L(-)-Methionin
L-Methionine (L-Methionin) is the L-isomer of Methionine. Methionine is an essential amino acid for human development and acts as a hepatoprotectant.
L-Methionine
Copy Product Info😃Good
Purity: 99.84%
Catalog No. T4844Alias L-Methionin, L(-)-MethioninCas No. 63-68-3
L-Methionine (L-Methionin) is the L-isomer of Methionine. Methionine is an essential amino acid for human development and acts as a hepatoprotectant.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 200 mg | $30 | In Stock | In Stock | |
| 500 mg | $40 | In Stock | In Stock | |
| 1 g | $48 | In Stock | In Stock | |
| 2 g | $68 | - | In Stock | |
| 5 g | $113 | - | In Stock | |
| 10 g | $167 | - | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.84%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
L-Methionine AI Summary
L-Methionine exhibits a diverse range of bioactivities and properties. It acts as an inhibitor of several enzymes, including recombinant S-adenosyl L-Methionine synthetase (alpha-isoform) in rat liver with a Km value of 70000.0 nM, and Gamma-glutamyltranspeptidase in rat kidney with a Ki value of 26900000.0 nM. Furthermore, it shows Km values of 5000.0 nM and 15600.0 nM for substrate activity with rat Methionine adenosyltransferase II and normal tissue form of rat Methionine Adenosyltransferase, respectively. Its moderate lipophilicity is indicated by a logP value of 1.84 and a clogP of 1.9.
L-Methionine also exhibits significant activity in promoting the formation of S-Adenosyl methionine with a Kcat value of 12.0 /min and a Km value of 2600000.0 nM, alongside a ratio of Kcat to Km of 4.6 /mM/min. Its protective properties are evident in hepatocytes, reducing cytotoxicity in Wistar rats from galactosamine with low observed cytotoxicity itself. Remarkably, it induces disease resistance in Oryza sativa Nipponbare (rice), increasing phenylalanine ammonia lyase activity by a factor of 10 and significantly elevating momilactone and sakuranetin levels.
Despite demonstrating moderate liver toxicity in rats, clinical-chemistry results indicate it may not have significant liver toxicity in humans. Antioxidant activity is observed with a trolox equivalent of 1.126 umolequiv/umol in the ORAC-FL assay. L-Methionine acts as both a cis-inhibitor (IC50 of 170000 nM) and a trans-stimulator of human LAT1, showing activity in promoting [3H]-gabapentin efflux.
Other activities include inhibition of PKM2 by 65.0% and selective inhibition of SARS-CoV-2 replication in Caco-2 and VERO-6 cells, though demonstrating low antiviral activity in HRCE cells. Additionally, it inhibits human HDAC6 enzymes and shows limited inhibitory activity against human LAT1 and SARS-CoV-2 3CL-Pro protease.
Overall, L-Methionine exhibits multiple bioactivities, making it a candidate for diverse biological and pharmacological studies..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | L-Methionine (L-Methionin) is the L-isomer of Methionine. Methionine is an essential amino acid for human development and acts as a hepatoprotectant. |
| Synonyms | L-Methionin, L(-)-Methionin |
| Molecular Weight | 149.21 |
| Formula | C5H11NO2S |
| Cas No. | 63-68-3 |
| Smiles | [C@@H](C(O)=O)(CCSC)N |
| Relative Density. | 1.34 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: Insoluble H2O: 50 mg/mL (335.1 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy L-Methionine | purchase L-Methionine | L-Methionine cost | order L-Methionine | L-Methionine chemical structure | L-Methionine formula | L-Methionine molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.