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MRT 67307 dihydrochloride

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Purity:98.43%

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COA HNMR HPLC

MRT 67307 dihydrochloride

Catalog No. T36994Cas No. 1781882-89-0

MRT 67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells.

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Pack Size	Price	Availability
5 mg	$52	In Stock
10 mg	Inquiry	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$67	In Stock

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Product Introduction

Bioactivity

Description

In vitro

MRT 67307 dihydrochloride inhibits IKKϵ and TBK1 with IC50 of 160 and 19 nM when assayed at 0.1 mM ATP in vitro, but did not inhibit IKKα or IKKβ even at 10 μM[1]. MRT 67307 dihydrochloride (2 μM) prevents the phosphorylation of IRF3 in bone-marrow-derived macrophages (BMDMs). MRT 67307 dihydrochloride (2 μM) dose not suppresse the activation of JNK or p38 MAPK by poly(I:C)[1]. MRT 67307 dihydrochloride (1 nM-10 μM) prevents the production of IFNβ in macrophages[1]. MRT 67307 dihydrochloride (10 μM) is sufficient to reduce phospho-ATG13 to control levels[2]. MRT 67307 dihydrochloride (10 μM) blocks autophagy in mouse embryonic fibroblasts (MEFs)[2]. MRT 67307 dihydrochloride (5 µM; 4 h) abrogates TBK1/IKKε-induced CYLD phosphorylation in 293T cells[3].

Chemical Properties

Molecular Weight	537.53
Formula	C26H38Cl2N6O2
Cas No.	1781882-89-0

Storage & Solubility Information

Storage

|Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 82.8 mg/mL (154 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8604 mL	9.3018 mL	18.6036 mL	93.0181 mL
5 mM	0.3721 mL	1.8604 mL	3.7207 mL	18.6036 mL
10 mM	0.1860 mL	0.9302 mL	1.8604 mL	9.3018 mL
20 mM	0.0930 mL	0.4651 mL	0.9302 mL	4.6509 mL
50 mM	0.0372 mL	0.1860 mL	0.3721 mL	1.8604 mL
100 mM	0.0186 mL	0.0930 mL	0.1860 mL	0.9302 mL

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