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Anti-Leptin Receptor Antibody (8U342)
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Catalog No. TMAY-00608
Alias OB-R, OBR, leptin receptor, LEPRD, LEP-R, CD295
Anti-Leptin Receptor Antibody (8U342) is a Mouse antibody targeting Leptin Receptor. Anti-Leptin Receptor Antibody (8U342) can be used in ELISA.
Anti-Leptin Receptor Antibody (8U342)
Anti-Leptin Receptor Antibody (8U342)
😃Good
Catalog No. TMAY-00608Alias OB-R, OBR, leptin receptor, LEPRD, LEP-R, CD295
Anti-Leptin Receptor Antibody (8U342) is a Mouse antibody targeting Leptin Receptor. Anti-Leptin Receptor Antibody (8U342) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Leptin Receptor Antibody (8U342) is a Mouse antibody targeting Leptin Receptor. Anti-Leptin Receptor Antibody (8U342) can be used in ELISA. |
| Alias | OB-R, OBR, leptin receptor, LEPRD, LEP-R, CD295 |
| Ig Type | Monoclonal Mouse IgG2a |
| Clone | 8U342 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Leptin Receptor/CD295 (rh Leptin Receptor/CD295; TMPY-01725; NP_002294.2; Met1-Asp839). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight) and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Leptin Receptor/CD295 is transmembrane catalytic receptors found on NPY/AgRP and alpha-MSH/CART neurons in hypothalamic nuclei. Leptin receptors (Ob-Rs) are coded for by one human gene that produces six different isoforms; Ob-Ra - Ob-Rf. Ob-Rs exist as constitutive dimers at physiological expression levels. Only the Ob-Rb isoform can transduce intracellular signals and does so through activation of the JAK2/STAT3, PI 3-K, and MAPK signaling cascades. Activation of Ob-Rs mediates transcriptional regulation of the hypothalamic melanocortin pathway and downregulates endocannabinoid expression. Leptin acts via leptin receptors. Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese individuals, Ob-Ra (which is involved in the active transport of leptin across the blood-brain barrier) expression is downregulated and the individual may be unresponsive to leptin signals. Ob-R antagonists are of great interest in the development of pharmacological treatments for obesity. Mutations in the Leptin Receptor/CD295 have been associated with obesity and pituitary dysfunction. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human Leptin Receptor/CD295 Protein (TMPY-01725) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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