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Idalopirdine Hydrochloride

Name: Idalopirdine Hydrochloride
Brand: TargetMol
SKU: T22936
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T22936Cas No. 467458-02-2

Alias Lu AE58054 Hydrochloride, Idalopirdine HCl

Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is an in-vivo binding affinity and effect, in-vitro selectivity and potency of 5-HT(6)R antagonist (Ki: 0.83 nM).

Idalopirdine Hydrochloride

🥰Excellent

Purity: 99.77%

Catalog No. T22936Alias Lu AE58054 Hydrochloride, Idalopirdine HClCas No. 467458-02-2

Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is an in-vivo binding affinity and effect, in-vitro selectivity and potency of 5-HT(6)R antagonist (Ki: 0.83 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
5 mg	$83	In Stock	In Stock
10 mg	$119	In Stock	In Stock
25 mg	$208	In Stock	In Stock
50 mg	$312	In Stock	In Stock
100 mg	$441	In Stock	In Stock
200 mg	$593	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.77%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is an in-vivo binding affinity and effect, in-vitro selectivity and potency of 5-HT(6)R antagonist (Ki: 0.83 nM).
Targets&IC50	5-HT6 receptor:0.83 nM(Ki)
In vitro	In the 5-HT(6) GTP gamma S efficacy assay, Lu AE58054 showed potent inhibition of 5-HT-mediated activation. Apart from medium affinity to adrenergic alpha (1B)- and alpha(1A)-adrenoreceptors, Lu AE58054 shows >50-fold selectivity compared with more than 70 targets examined[1].
In vivo	In the rats model, Orally administered Lu AE58054 inhibited binding of the 5-HT6 antagonist Lu AE60157 (ED50: 2.7 mg/kg). Administration of Lu AE58054 in a dose range (5–20 mg/kg) leading to above 65% 5-HT6R binding, which reversed cognitive impairment in rats treatment with phencyclidine. These results indicate that Lu AE58054 is a potent antagonist of 5-HT6Rs with good oral bioavailability in the rat model of cognitive impairment in schizophrenia[1].
Synonyms	Lu AE58054 Hydrochloride, Idalopirdine HCl

Chemical Properties

Molecular Weight	434.83
Formula	C₂₀H₂₀ClF₅N₂O
Cas No.	467458-02-2
Smiles	Cl.FC(F)C(F)(F)COc1cccc(CNCCc2c[nH]c3cc(F)ccc23)c1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 50 mg/mL (114.99 mM), Sonication is recommended.

DMSO: 20 mg/mL (45.99 mM), Sonication is recommended.

H2O: 3 mg/mL (6.9 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (4.6 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.2997 mL	11.4987 mL	22.9975 mL	114.9875 mL
5 mM	0.4599 mL	2.2997 mL	4.5995 mL	22.9975 mL

DMSO/Ethanol

	1mg	5mg	10mg	50mg
10 mM	0.2300 mL	1.1499 mL	2.2997 mL	11.4987 mL
20 mM	0.1150 mL	0.5749 mL	1.1499 mL	5.7494 mL

Ethanol

	1mg	5mg	10mg	50mg
50 mM	0.0460 mL	0.2300 mL	0.4599 mL	2.2997 mL
100 mM	0.0230 mL	0.1150 mL	0.2300 mL	1.1499 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc