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Anti-EphA2 Antibody (8N84)
😃Good
Catalog No. TMAY-03368
Alias Sek-2, Sek2, Myk2, EPH receptor A2, Eck, AW545284
Anti-EphA2 Antibody (8N84) is a Rabbit antibody targeting EphA2. Anti-EphA2 Antibody (8N84) can be used in ELISA,FCM.
Anti-EphA2 Antibody (8N84)
Anti-EphA2 Antibody (8N84)
😃Good
Catalog No. TMAY-03368Alias Sek-2, Sek2, Myk2, EPH receptor A2, Eck, AW545284
Anti-EphA2 Antibody (8N84) is a Rabbit antibody targeting EphA2. Anti-EphA2 Antibody (8N84) can be used in ELISA,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA, FCM Reactivity: Mouse |
| Alias | Sek-2, Sek2, Myk2, EPH receptor A2, Eck, AW545284 |
| Ig Type | Rabbit IgG |
| Clone | 8N84 |
| Reactivity | Mouse |
| Verified Activity | Flow cytometric analysis of Mouse EphA2 expression on MS1 cells. Cells were stained with purified anti-Mouse EphA2, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | ELISA,FCM |
| Recommended Dose | ELISA: 1:5000-1:10000; FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse EphA2 (rM EphA2; TMPY-01777; NP_034269.2; Met1-Asn535). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Eph receptor A2 (Ephrin type-A receptor 2 or EphA2) is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptors' corresponding family of ligands are the ephrins anchored to cell surfaces. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps. They have also been found implicated in embryonic patterning, neuronal targeting, vascular development and adult neovascularization. The large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system. Furthermore, elevated expression of Eph receptors and ephrin ligands is associated with tumors and associated tumor vasculature, suggesting the Eph receptors and ephrin ligands also play critical roles in tumor angiogenesis and tumor growth. Unlike most Eph kinases, which are primarily expressed during development, EphA2 is primarily found in adult human epithelial cells. The cellular functions of EphA2 may be regulating cell growth, survival, migration, and angiogenesis.Unlike other receptor tyrosine kinases, ligand binding is not necessary for EphA2. Rather, the ligand appears to regulate EphA2 subcellular localization and its interactions with downstream adapter and signaling proteins. Eph receptor A2(EphA2) has been demonstrated to critically regulate tumor cell growth, migration and invasiveness. Eph receptor A2(EphA2) is frequently overexpressed and functionally altered in aggressive tumor cells, and that these changes promote metastatic character. |
| Conjucates | Unconjugated |
| Others Formats | FITC/PE |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Protein: Mouse EphA2 protein (TMPY-01777) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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