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Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody

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Catalog No. TMAC-03329

Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKC beta (Thr641). Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody can be used in WB,IHC,IF.

Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody

Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody

😃Good
Catalog No. TMAC-03329
Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKC beta (Thr641). Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody can be used in WB,IHC,IF.
Pack SizePriceAvailabilityQuantity
50 μL$2187-10 days
100 μL$3177-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKC beta (Thr641). Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody can be used in WB,IHC,IF.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
AppearanceLiquid
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundCalcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell suvival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652', leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. Also involved in triglyceride homeostasis. Serves as the receptor for phorbol esters, a class of tumor promoters.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of threonine 641 (E-L-T(p)-P-T) derived from Human PKCb
Antigen Species
human
Uniprot ID
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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