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Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody (Synonyms: p-PKC beta (Thr641), p-PKC beta (T641), PKC beta...)

Catalog No. TMAC-03329 Copy Product Info
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Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKC beta (Thr641). Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody can be used in IF,IHC,WB.

Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody

Copy Product Info
🥰Excellent
Catalog No. TMAC-03329
Synonyms p-PKC beta (Thr641), p-PKC beta (T641), PKC beta (p-Thr641), PKC beta (p-T641)

Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKC beta (Thr641). Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody can be used in IF,IHC,WB.

Anti-Phospho-PKC beta
(Thr641) Polyclonal Antibody
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2187-10 days7-10 days
100 μL$3177-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKC beta (Thr641). Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody can be used in IF,IHC,WB.
Synonymsp-PKC beta (Thr641), p-PKC beta (T641), PKC beta (p-Thr641), PKC beta (p-T641)
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Verified Activity
1. Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue, using PKCb (phospho-Thr641) antibody (TMAC-03329).
2. Immunofluorescence staining of methanol-fixed MCF7 cells using PKCb (phospho-Thr641) antibody (TMAC-03329, Red).
3. Western blot analysis of extracts from JK cells untreated or treated with PMA using PKCβ (phospho-Thr641) antibody TMAC-03329.
verifiedActivityverifiedActivityverifiedActivity
Application
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
AppearanceLiquid
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundCalcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell suvival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652', leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. Also involved in triglyceride homeostasis. Serves as the receptor for phorbol esters, a class of tumor promoters.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of threonine 641 (E-L-T(p)-P-T) derived from Human PKCb
Antigen Species
human
Uniprot ID
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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