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Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody
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Catalog No. TMAC-03329
Alias p-PKC beta (Thr641), p-PKC beta (T641), PKC beta (p-Thr641), PKC beta (p-T641)
Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKC beta (Thr641). Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody can be used in IF,IHC,WB.
Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody
Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody
😃Good
Catalog No. TMAC-03329Alias p-PKC beta (Thr641), p-PKC beta (T641), PKC beta (p-Thr641), PKC beta (p-T641)
Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKC beta (Thr641). Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody can be used in IF,IHC,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $218 | 7-10 days | 7-10 days | |
| 100 μL | $317 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Chemical Properties
| Description | Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKC beta (Thr641). Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody can be used in IF,IHC,WB. |
| Synonyms | p-PKC beta (Thr641), p-PKC beta (T641), PKC beta (p-Thr641), PKC beta (p-T641) |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue, using PKCb (phospho-Thr641) antibody (TMAC-03329). 2. Immunofluorescence staining of methanol-fixed MCF7 cells using PKCb (phospho-Thr641) antibody (TMAC-03329, Red). 3. Western blot analysis of extracts from JK cells untreated or treated with PMA using PKCβ (phospho-Thr641) antibody TMAC-03329.    |
| Application | |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Appearance | Liquid |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell suvival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652', leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. Also involved in triglyceride homeostasis. Serves as the receptor for phorbol esters, a class of tumor promoters. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of threonine 641 (E-L-T(p)-P-T) derived from Human PKCb |
| Antigen Species | human |
| Uniprot ID |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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