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Anti-HAI-2/SPINT2 Antibody (5O92)
🥰Excellent
Catalog No. TMAY-03054
Anti-HAI-2/SPINT2 Antibody (5O92) is a Rabbit antibody targeting HAI-2/SPINT2. Anti-HAI-2/SPINT2 Antibody (5O92) can be used in ELISA.
Anti-HAI-2/SPINT2 Antibody (5O92)
Anti-HAI-2/SPINT2 Antibody (5O92)
🥰Excellent
Catalog No. TMAY-03054
Anti-HAI-2/SPINT2 Antibody (5O92) is a Rabbit antibody targeting HAI-2/SPINT2. Anti-HAI-2/SPINT2 Antibody (5O92) can be used in ELISA.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-HAI-2/SPINT2 Antibody (5O92) is a Rabbit antibody targeting HAI-2/SPINT2. Anti-HAI-2/SPINT2 Antibody (5O92) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 5O92 |
| Reactivity | Mouse |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SPINT2 extracellular domain (rM SPINT2; TMPY-00926; NP_001076017.1; Met 1-Lys 140). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Choanal (CA) and gastrointestinal atresias (GA) are an important feature of syndromic congenital sodium diarrhea (sCSD), a disorder recently associated with mutations in the gene for serine protease inhibitor type 2 (SPINT2). The SPINT2 gene is epigenetically silenced or downregulated in human cancers, altering the balance of HGF activation/inhibition ratio, which contributes to cancer development and progression. SPINT2 is a tumor suppressor gene that inhibits proteases implicated in cancer progression, like HGFA, hepsin and matriptase. Loss of SPINT2 expression in tumors has been associated with gene promoter hypermethylation. SPINT2 (serine peptidase inhibitor Kunitz type 2), a proteolytic inhibitor of hepatocyte growth factor activator (HGFA), has a significant role in the suppression of the HGF-MET pathway and malignant melanoma progression. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse SPINT2 protein (TMPY-00926) |
| Antigen Species | Mouse |
| Biology Area | Serine Proteases and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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