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BOS-318

Name: BOS-318
Brand: TargetMol
SKU: T9964
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9964Cas No. 2387633-15-8

BOS-318 is a Furin inhibitor with IC50 of 1.9 nM, and has the characteristics of slow dissociation, high selectivity, and cell permeability.

BOS-318

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Purity: 99.66%

Catalog No. T9964Cas No. 2387633-15-8

BOS-318 is a Furin inhibitor with IC50 of 1.9 nM, and has the characteristics of slow dissociation, high selectivity, and cell permeability.

Pack Size	Price	Availability
1 mg	$41	In Stock
5 mg	$97	In Stock
10 mg	$159	In Stock
25 mg	$322	In Stock
50 mg	$513	In Stock
100 mg	$747	In Stock
1 mL x 10 mM (in DMSO)	$123	In Stock

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Purity:99.66%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	BOS-318 is a Furin inhibitor with IC50 of 1.9 nM, and has the characteristics of slow dissociation, high selectivity, and cell permeability.
Targets&IC50	endogenous proteases (U2OS cells):23.5 nM, Furin:1.9 nM
In vitro	METHODS: PEA and CuFi-1 cells were treated with BOS-318 (0.03, 0.1, 0.3, 1 μM, 72 hours) and PEA and cell viability was monitored to investigate the protective effect of BOS-318 against the toxic effects of bacterial toxins activated by Furin protein. RESULTS The cell viability of CuFi-1 cells treated with PEA was approximately 2% of the control level. A single 0.3 μM dose of BOS-318 significantly increased the cell viability of PEA-treated cells to approximately 88% of the control level. [1]

Chemical Properties

Molecular Weight	571.5
Formula	C₂₈H₃₂Cl₂N₆O₃
Cas No.	2387633-15-8
Smiles	CN1CCN(CC1)c1ncc(Oc2cc(CN3CCC(CC(O)=O)CC3)cc(n2)-c2cc(Cl)cc(Cl)c2)cn1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 35.5 mg/mL (62.12 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7498 mL	8.7489 mL	17.4978 mL	87.4891 mL
5 mM	0.3500 mL	1.7498 mL	3.4996 mL	17.4978 mL
10 mM	0.1750 mL	0.8749 mL	1.7498 mL	8.7489 mL
20 mM	0.0875 mL	0.4374 mL	0.8749 mL	4.3745 mL
50 mM	0.0350 mL	0.1750 mL	0.3500 mL	1.7498 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc