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BOS-318

Name: BOS-318
Brand: TargetMol
SKU: T9964
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9964Cas No. 2387633-15-8

BOS-318 is a Furin inhibitor with IC50 of 1.9 nM, and has the characteristics of slow dissociation, high selectivity, and cell permeability.

BOS-318

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Purity: 99.66%

Catalog No. T9964Cas No. 2387633-15-8

BOS-318 is a Furin inhibitor with IC50 of 1.9 nM, and has the characteristics of slow dissociation, high selectivity, and cell permeability.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
5 mg	$97	In Stock	In Stock
10 mg	$159	In Stock	In Stock
25 mg	$322	In Stock	In Stock
50 mg	$513	In Stock	In Stock
100 mg	$747	-	In Stock
1 mL x 10 mM (in DMSO)	$123	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.66%

Appearance:Solid

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	BOS-318 is a Furin inhibitor with IC50 of 1.9 nM, and has the characteristics of slow dissociation, high selectivity, and cell permeability.
Targets&IC50	endogenous proteases (U2OS cells):23.5 nM, Furin:1.9 nM
In vitro	METHODS: PEA and CuFi-1 cells were treated with BOS-318 (0.03, 0.1, 0.3, 1 μM, 72 hours) and PEA and cell viability was monitored to investigate the protective effect of BOS-318 against the toxic effects of bacterial toxins activated by Furin protein. RESULTS The cell viability of CuFi-1 cells treated with PEA was approximately 2% of the control level. A single 0.3 μM dose of BOS-318 significantly increased the cell viability of PEA-treated cells to approximately 88% of the control level. [1]

Chemical Properties

Molecular Weight	571.5
Formula	C₂₈H₃₂Cl₂N₆O₃
Cas No.	2387633-15-8
Smiles	CN1CCN(CC1)c1ncc(Oc2cc(CN3CCC(CC(O)=O)CC3)cc(n2)-c2cc(Cl)cc(Cl)c2)cn1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 35.5 mg/mL (62.12 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7498 mL	8.7489 mL	17.4978 mL	87.4891 mL
5 mM	0.3500 mL	1.7498 mL	3.4996 mL	17.4978 mL
10 mM	0.1750 mL	0.8749 mL	1.7498 mL	8.7489 mL
20 mM	0.0875 mL	0.4374 mL	0.8749 mL	4.3745 mL
50 mM	0.0350 mL	0.1750 mL	0.3500 mL	1.7498 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc