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Aristolochic acid B
🥰Excellent
Catalog No. T7031Cas No. 475-80-9
Alias Aristolochic Acid II
Aristolochic acid B (Aristolochic Acid II) is a natural product from the Aristolochaceae taxon and is one of the main components of aristolochic acid. Aristolochic acid is a mutagen and carcinogen, and Aristolochic acid B (Aristolochic Acid II) can show a greater carcinogenic risk in vivo than Aristolochic acid I.
Aristolochic acid B
🥰Excellent
Purity: 99.99%
Catalog No. T7031Alias Aristolochic Acid IICas No. 475-80-9
Aristolochic acid B (Aristolochic Acid II) is a natural product from the Aristolochaceae taxon and is one of the main components of aristolochic acid. Aristolochic acid is a mutagen and carcinogen, and Aristolochic acid B (Aristolochic Acid II) can show a greater carcinogenic risk in vivo than Aristolochic acid I.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $72 | In Stock | |
| 5 mg | $189 | In Stock | |
| 10 mg | $278 | In Stock | |
| 25 mg | $475 | In Stock | |
| 50 mg | $682 | In Stock | |
| 100 mg | $948 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $189 | In Stock |
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Purity:99.99%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Aristolochic acid B (Aristolochic Acid II) is a natural product from the Aristolochaceae taxon and is one of the main components of aristolochic acid. Aristolochic acid is a mutagen and carcinogen, and Aristolochic acid B (Aristolochic Acid II) can show a greater carcinogenic risk in vivo than Aristolochic acid I. |
| In vivo | METHODS: Aristolochic acid B (Aristolochic Acid II) (5 mg/kg, intragastrically, 5 times a week for 6 weeks) was compared for DNA adduct formation and mutagenicity in the kidneys of gptδ transgenic mice. RESULTS Aristolochic acid B (Aristolochic Acid II) induced mutations at a frequency nearly two-fold higher than that induced by aristolochic acid I, showing a higher carcinogenic risk in vivo than aristolochic acid I, which may be at least partly the result of its elevated levels in the kidneys and plasma. [1] |
| Synonyms | Aristolochic Acid II |
| Molecular Weight | 311.25 |
| Formula | C16H9NO6 |
| Cas No. | 475-80-9 |
| Smiles | OC(=O)c1cc2OCOc2c2c3ccccc3cc([N+]([O-])=O)c12 |
| Relative Density. | 1.61 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (32.13 mM), Sonication is recommended.  Chloroform: Soluble | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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