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Aristolochic acid B

Name: Aristolochic acid B
Brand: TargetMol
SKU: T7031
Price: 72 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7031Cas No. 475-80-9

Alias Aristolochic Acid II

Aristolochic acid B (Aristolochic Acid II) is a natural product from the Aristolochaceae taxon and is one of the main components of aristolochic acid. Aristolochic acid is a mutagen and carcinogen, and Aristolochic acid B (Aristolochic Acid II) can show a greater carcinogenic risk in vivo than Aristolochic acid I.

Aristolochic acid B

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Purity: 99.99%

Catalog No. T7031Alias Aristolochic Acid IICas No. 475-80-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$72	In Stock	In Stock
5 mg	$189	In Stock	In Stock
10 mg	$278	In Stock	In Stock
25 mg	$475	In Stock	In Stock
50 mg	$682	In Stock	In Stock
100 mg	$948	-	In Stock
1 mL x 10 mM (in DMSO)	$189	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Aristolochic acid B AI Summary

Aristolochic acid B exhibits bioactivity by inhibiting CDK2, although it does so with an IC50 value greater than 20000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Aristolochic acid B (Aristolochic Acid II) is a natural product from the Aristolochaceae taxon and is one of the main components of aristolochic acid. Aristolochic acid is a mutagen and carcinogen, and Aristolochic acid B (Aristolochic Acid II) can show a greater carcinogenic risk in vivo than Aristolochic acid I.
In vivo	METHODS: Aristolochic acid B (Aristolochic Acid II) (5 mg/kg, intragastrically, 5 times a week for 6 weeks) was compared for DNA adduct formation and mutagenicity in the kidneys of gptδ transgenic mice. RESULTS Aristolochic acid B (Aristolochic Acid II) induced mutations at a frequency nearly two-fold higher than that induced by aristolochic acid I, showing a higher carcinogenic risk in vivo than aristolochic acid I, which may be at least partly the result of its elevated levels in the kidneys and plasma. [1]
Synonyms	Aristolochic Acid II

Chemical Properties

Molecular Weight	311.25
Formula	C₁₆H₉NO₆
Cas No.	475-80-9
Smiles	OC(=O)c1cc2OCOc2c2c3ccccc3cc([N+]([O-])=O)c12
Relative Density.	1.61 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (32.13 mM), Sonication is recommended.

Chloroform: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2129 mL	16.0643 mL	32.1285 mL	160.6426 mL
5 mM	0.6426 mL	3.2129 mL	6.4257 mL	32.1285 mL
10 mM	0.3213 mL	1.6064 mL	3.2129 mL	16.0643 mL
20 mM	0.1606 mL	0.8032 mL	1.6064 mL	8.0321 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc