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L-Alanine

Name: L-Alanine
Brand: TargetMol
SKU: TJO2729
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TJO2729Cas No. 56-41-7

Alias L-2-Aminopropionic acid, alanine

L-Alanine (L-2-Aminopropionic acid) is an Amino Acid. The chemical classification of alanine is Amino Acids. Alanine is a small non-essential amino acid in humans, Alanine is one of the most widely used for protein construction and is involved in the metabolism of tryptophan and vitamin pyridoxine.

L-Alanine

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Purity: 99.83%

Catalog No. TJO2729Alias L-2-Aminopropionic acid, alanineCas No. 56-41-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$41	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

L-Alanine AI Summary

L-Alanine has been tested for various biological activities across different assays. It activates carbonic anhydrase isozymes with KA values of 54.0 µM (hCA I), 150.0 µM (hCA II), and 66.0 µM (bCA IV). It shows bioactivity on Alanine racemase from *Pseudomonas aeruginosa* with a Km value of 14.2 mM, and inhibits the N-methyl-D-aspartate glutamate receptor 1 in rats with IC50 values of 78.0 µM and 198.0 µM for different conditions. Additionally, it inhibits human Tyrosyl-DNA Phosphodiesterase (TDP1) and Human Apurinic/apyrimidinic Endonuclease 1 (APE1) with potencies of 2.5 µM and 354.8 nM respectively. It also inhibits human PAT1-mediated L-[3H]proline uptake in Caco2 cells with a Ki value of 2.8 mM. The compound promotes insulin release in rat BRIN-BD11 cells at 10 mM concentration, and inhibits ASCT2 mediated [3H]-D-serine uptake in rat hippocampal astrocytes by 25% at 1 mM concentration. It shows antiviral activity against SARS-CoV-2 in both Caco-2 and VERO-6 cells, with marginal inhibition rates. Additionally, it displays inhibitory activity against SARS-CoV-2 3CL-Pro protease and less than 50% inhibition in binding assays for FIBCD1 and acetylated BSA. L-Alanine also exhibits substrate activity at *Escherichia coli* B alanine racemase (Vmax of 6360 /min, Km of 1.3 mM) and HDAC6 inhibition varying from -21.28% to -3.75% depending on the peptide substrate. Despite this, it shows limited overall bioactivity as the AC50 values in all assays exceed 30.0 µM, suggesting minimal impact on the tested biological pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	L-Alanine (L-2-Aminopropionic acid) is an Amino Acid. The chemical classification of alanine is Amino Acids. Alanine is a small non-essential amino acid in humans, Alanine is one of the most widely used for protein construction and is involved in the metabolism of tryptophan and vitamin pyridoxine.
Synonyms	L-2-Aminopropionic acid, alanine

Chemical Properties

Molecular Weight	89.09
Formula	C₃H₇NO₂
Cas No.	56-41-7
Smiles	[C@@H](C(O)=O)(C)N
Relative Density.	1.432 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: 71.43 mg/mL (801.77 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	11.2246 mL	56.1230 mL	112.2460 mL	561.2302 mL
5 mM	2.2449 mL	11.2246 mL	22.4492 mL	112.2460 mL
10 mM	1.1225 mL	5.6123 mL	11.2246 mL	56.1230 mL
20 mM	0.5612 mL	2.8062 mL	5.6123 mL	28.0615 mL
50 mM	0.2245 mL	1.1225 mL	2.2449 mL	11.2246 mL
100 mM	0.1122 mL	0.5612 mL	1.1225 mL	5.6123 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc