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L-Ascorbic acid

L-Ascorbic acid
L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-Ascorbic acid is used in the treatment of scurvy.
Catalog No. T0928Cas No. 50-81-7
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Purity:99.89%
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L-Ascorbic acid

Catalog No. T0928Cas No. 50-81-7

L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-Ascorbic acid is used in the treatment of scurvy.
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Pack SizePriceAvailabilityQuantity
1 g$42In Stock
1 mL x 10 mM (in DMSO)$30In Stock
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Product Introduction

Bioactivity
Description
L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-Ascorbic acid is used in the treatment of scurvy.
In vitro
METHODS: Human osteosarcoma cells MG-63 were treated with L-Ascorbic acid (62.5-1000 µM) for 3-24 h. Cell viability was measured by XTT Assay.
RESULTS: Cell viability was consistently >95% when cells were treated with L-Ascorbic acid at concentrations of 0-250 µM. When higher concentrations were used, a dose-dependent decrease in cell viability was observed. [1]
METHODS: Melanoma cells WM1366 were treated with L-Ascorbic acid (5-50 µM) for 24 h. The expression levels of target proteins were measured using Western Blot.
RESULTS: The lowest concentration of L-Ascorbic acid (5 µM) significantly reduced the normoxic expression of HIF-1α protein in human melanoma cell lines. [2]
In vivo
METHODS: L-Ascorbic acid (1-4.5 g/kg) was administered intraperitoneally to irradiated C57BL/6 mice to detect radioprotective activity.
RESULTS: Administration of 3 g/kg L-Ascorbic acid immediately after exposure significantly increased the survival rate of mice after 7-8 Gy WBI. However, administration of less than 3 g/kg L-Ascorbic acid was ineffective, and 4 g/kg and above was harmful to mice. [3]
METHODS: To investigate the effects on amnesia, L-Ascorbic acid (60-160 mg/kg) was administered intraperitoneally to diazepam, scopolamine, and aging-induced amnesic Swiss mice once daily for 3-8 days.
RESULTS: L-Ascorbic acid improved learning and memory in aging mice, as evidenced by decreased transfer latency and increased descending latency. [4]
AliasVitamin C, Ascorbic acid, L(+)-Ascorbic acid, L-Ascorbate
Chemical Properties
Molecular Weight176.12
FormulaC6H8O6
Cas No.50-81-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 35.7 mg/mL (202.8 mM)
DMSO: 60 mg/mL (340.68 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM5.6779 mL28.3897 mL56.7795 mL283.8973 mL
5 mM1.1356 mL5.6779 mL11.3559 mL56.7795 mL
10 mM0.5678 mL2.8390 mL5.6779 mL28.3897 mL
20 mM0.2839 mL1.4195 mL2.8390 mL14.1949 mL
50 mM0.1136 mL0.5678 mL1.1356 mL5.6779 mL
100 mM0.0568 mL0.2839 mL0.5678 mL2.8390 mL

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