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(2S)-6-Prenylnaringenin

Name: (2S)-6-Prenylnaringenin
Brand: TargetMol
SKU: TN1325
Price: 93 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1325Cas No. 68236-13-5

Alias 6-Prenylnaringenin, 6-PN

(2S)-6-Prenylnaringenin (6-Prenylnaringenin) is an isomer of the potent phytoestrogen, 8-prenylnaringenin. (2S)-6-Prenylnaringenin is the most potent compound in the forebrain and acts as a positive allosteric modulator of GABAA at the α+β binding site.

(2S)-6-Prenylnaringenin

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Purity: 99.47%

Catalog No. TN1325Alias 6-Prenylnaringenin, 6-PNCas No. 68236-13-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$93	In Stock	In Stock
5 mg	$243	In Stock	In Stock
10 mg	$359	In Stock	In Stock
25 mg	$596	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$246	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.47%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	(2S)-6-Prenylnaringenin (6-Prenylnaringenin) is an isomer of the potent phytoestrogen, 8-prenylnaringenin. (2S)-6-Prenylnaringenin is the most potent compound in the forebrain and acts as a positive allosteric modulator of GABAA at the α+β binding site.
Targets&IC50	GABAA:3.7 μM
In vitro	In native GABAA receptors, 6-Prenylnaringenin potentiates GABA-induced displacement of [3H]EBOB binding in a concentration-dependent manner with IC50s of 3.7 μM[1]. 6-Prenylnaringenin displays a modulatory activity at low micromolar concentrations.
Synonyms	6-Prenylnaringenin, 6-PN

Chemical Properties

Molecular Weight	340.37
Formula	C₂₀H₂₀O₅
Cas No.	68236-13-5
Smiles	CC(C)=CCc1c(O)cc2O[C@@H](CC(=O)c2c1O)c1ccc(O)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95.3 mg/mL (279.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9380 mL	14.6899 mL	29.3798 mL	146.8990 mL
5 mM	0.5876 mL	2.9380 mL	5.8760 mL	29.3798 mL
10 mM	0.2938 mL	1.4690 mL	2.9380 mL	14.6899 mL
20 mM	0.1469 mL	0.7345 mL	1.4690 mL	7.3449 mL
50 mM	0.0588 mL	0.2938 mL	0.5876 mL	2.9380 mL
100 mM	0.0294 mL	0.1469 mL	0.2938 mL	1.4690 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc