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Anti-CD22 Monoclonal Antibody (5Q81)

(Synonyms: SIGLEC-2, SIGLEC2) Copy Product Info
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Synonyms: SIGLEC-2, SIGLEC2

Catalog No. TMAT-0329 Copy Product Info
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Anti-CD22 Monoclonal Antibody (5Q81) is a Mouse antibody targeting CD22. Anti-CD22 Monoclonal Antibody (5Q81) can be used in WB,IHC,IF,FCM.

Anti-CD22 Monoclonal Antibody
(5Q81)

TargetMol
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Product Introduction

Bioactivity
Description
Anti-CD22 Monoclonal Antibody (5Q81) is a Mouse antibody targeting CD22. Anti-CD22 Monoclonal Antibody (5Q81) can be used in WB,IHC,IF,FCM.
SynonymsSIGLEC-2, SIGLEC2
Ig Type
IgG1
Clone
5Q81
Reactivity
Human
Application
WB
IHC
IF
FCM
Recommended Dose
WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/50-1/200; FCM: 1/200-1/400
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionHybridoma Monoclonal Antibody
PurificationPurified by protein A or protein G
AppearanceLiquid
FormulationPBS with 0.05% sodium azide
Concentration1 mg/ml
Research BackgroundCD22 may be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Purified recombinant fragment of human CD22 (AA: 621-725) expressed in E. Coli.
Antigen Species
Human
Gene Name
CD22
Gene ID
933
Protein Name
B-cell receptor CD22
Uniprot ID
P20273
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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