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[Leu5]-Enkephalin

Name: [Leu5]-Enkephalin
Brand: TargetMol
SKU: T7173
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7173Cas No. 58822-25-6

Alias Leu-enkephalin, Leucyl-enkephalin, Leucine enkephalin

[Leu5]-Enkephalin (Leu-enkephalin) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively)

[Leu5]-Enkephalin

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Purity: 99.88%

Catalog No. T7173Alias Leu-enkephalin, Leucyl-enkephalin, Leucine enkephalinCas No. 58822-25-6

[Leu5]-Enkephalin (Leu-enkephalin) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively)

Pack Size	Price	Availability
10 mg	$40	In Stock
25 mg	$77	In Stock
50 mg	$116	In Stock
100 mg	$163	In Stock

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Purity:99.88%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	[Leu5]-Enkephalin (Leu-enkephalin) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively)
In vivo	[Leu5]-Enkephalin is found in the brain, the brainstem, and the spinal cord as well as in the peripheral nervous system. Leu-Enkephalin (1 mg/kg) decreases the visceromotor response to colon distension in a mouse model of visceral pain induced by colorectal distension[1].
Synonyms	Leu-enkephalin, Leucyl-enkephalin, Leucine enkephalin

Chemical Properties

Molecular Weight	555.62
Formula	C₂₈H₃₇N₅O₇
Cas No.	58822-25-6
Smiles	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O
Relative Density.	1.274 g/cm3 (Predicted)
Sequence	Tyr-Gly-Gly-Phe-Leu
Sequence Short	YGGFL

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (269.97 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7998 mL	8.9990 mL	17.9979 mL	89.9896 mL
5 mM	0.3600 mL	1.7998 mL	3.5996 mL	17.9979 mL
10 mM	0.1800 mL	0.8999 mL	1.7998 mL	8.9990 mL
20 mM	0.0900 mL	0.4499 mL	0.8999 mL	4.4995 mL
50 mM	0.0360 mL	0.1800 mL	0.3600 mL	1.7998 mL
100 mM	0.0180 mL	0.0900 mL	0.1800 mL	0.8999 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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