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FGFR3 Protein, Human, Recombinant (alpha IIIb, His)

Catalog No. TMPY-00341
Synonyms: CEK2, HSFGFR3EX, fibroblast growth factor receptor 3, JTK4, FGFR3 α(IIIb), CD333, ACH

FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2.

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FGFR3 Protein, Human, Recombinant (alpha IIIb, His)
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200 μg In stock $ 583.00
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Biological Description
Technical Params
Product Properties
References and Literature
Biological Information Testing in progress
Description FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2.
Species Human
Expression System HEK293 Cells
Tag C-His
Accession Number P22607-2
Synonyms CEK2, HSFGFR3EX, fibroblast growth factor receptor 3, JTK4, FGFR3 α(IIIb), CD333, ACH
Construction The Human FGFR3(alpha(IIIb)) (NP_001156685.1) (Met1-Gly377) was expressed with a polyhistidine tag at the C-terminus.
Protein Purity > 95 % as determined by SDS-PAGE.

Molecular Weight 40 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer. FGFR3, a full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. CD333 is the receptor for acidic and basic fibroblast growth factors.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

References and Literature

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Keywords

FGFR3 Protein, Human, Recombinant (alpha IIIb, His) CEK2 JTK-4 HSFGFR3EX CEK 2 CEK-2 fibroblast growth factor receptor 3 JTK4 CD-333 FGFR3 α(IIIb) CD 333 JTK 4 CD333 ACH recombinant recombinant-proteins proteins protein

 

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