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Lupeol acetate (Synonyms: Lupeyl acetate, 3-Acetyllupeol)
Catalog No. TN1890 Copy Product Info
Purity: 99.84%
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Lupeol acetate is a derivative of Lupeol with anti-cancer, anti-inflammatory, anti-diabetic, anti-snake venom, anti-fertility effects and oral activity. It is able to inhibit rheumatoid arthritis by down-regulating inflammatory cytokines (TNF-α, IL-1β, MCP-1, COX-2, VEGF, granzyme B) and is cytotoxic to Hep-3B and A549 cells.
Lupeol acetate
Copy Product Info🥰Excellent
Catalog No. TN1890
Synonyms Lupeyl acetate, 3-Acetyllupeol
Lupeol acetate is a derivative of Lupeol with anti-cancer, anti-inflammatory, anti-diabetic, anti-snake venom, anti-fertility effects and oral activity. It is able to inhibit rheumatoid arthritis by down-regulating inflammatory cytokines (TNF-α, IL-1β, MCP-1, COX-2, VEGF, granzyme B) and is cytotoxic to Hep-3B and A549 cells.
Cas No. 1617-68-1
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $68 | - | In Stock | |
| 5 mg | $163 | - | In Stock | |
| 10 mg | $263 | - | In Stock | |
| 25 mg | $446 | - | In Stock | |
| 50 mg | $645 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $193 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.84%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Lupeol acetate is a derivative of Lupeol with anti-cancer, anti-inflammatory, anti-diabetic, anti-snake venom, anti-fertility effects and oral activity. It is able to inhibit rheumatoid arthritis by down-regulating inflammatory cytokines (TNF-α, IL-1β, MCP-1, COX-2, VEGF, granzyme B) and is cytotoxic to Hep-3B and A549 cells. |
| In vitro | Methods: Lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and bone marrow-derived macrophages (BMDM) were treated with Lupeol acetate (0-80μM) and TNF-α, IL-1β, COX-2, and MCP-1 were measured using Western blotting. In addition, bone formation was examined using reverse transcription-PCR (RT-PCR) and tartrate-resistant acid phosphatase (TRAP) staining. Results: Lupeol acetate inhibited the activation, migration, and formation of macrophage osteoclastogenesis in a dose-dependent manner. [3] |
| In vivo | Methods: DBA/1J mice with collagen-induced arthritis (CIA) were randomly divided into three groups: vehicle, Lupeol acetate-treated (50mg/kg), and curcumin-treated (100mg/kg). The therapeutic effects were determined by clinical scores, expression levels of serum cytokines including TNF-α and IL-1β, (18)F-fluorodeoxyglucose ((18)F-FDG) microPET/CT, and histopathology. Results: In RA-bearing mice, the expression of inflammatory-related cytokines was suppressed, and LA improved clinical symptoms and bone erosion. Lupeol acetate also significantly reduced the accumulation of (18)F-FDG in the joints of RA-bearing mice. Lupeol acetate significantly improved the symptoms of RA by downregulating the expression of inflammatory cytokines and osteoclastogenesis. [3] |
| Synonyms | Lupeyl acetate, 3-Acetyllupeol |
| Molecular Weight | 468.75 |
| Formula | C32H52O2 |
| Cas No. | 1617-68-1 |
| Smiles | C[C@]12[C@@]([C@@]3([C@@](C)(CC1)CC[C@H]3C(C)=C)[H])(CC[C@]4([C@@]2(C)CC[C@@]5([C@]4(C)CC[C@H](OC(C)=O)C5(C)C)[H])[H])[H] |
| Relative Density. | 1.01g/cm3 |
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | Ethanol: 1 mg/mL (2.13 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
Ethanol
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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