Shopping Cart

Your shopping cart is currently empty

Lupeol acetate

Name: Lupeol acetate
Brand: TargetMol
SKU: TN1890
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. TN1890Cas No. 1617-68-1

Alias Lupeyl acetate, 3-Acetyllupeol

Lupeol acetate is a derivative of Lupeol with anti-cancer, anti-inflammatory, anti-diabetic, anti-snake venom, anti-fertility effects and oral activity. It is able to inhibit rheumatoid arthritis by down-regulating inflammatory cytokines (TNF-α, IL-1β, MCP-1, COX-2, VEGF, granzyme B) and is cytotoxic to Hep-3B and A549 cells.

Lupeol acetate

Copy Product Info

😃Good

Purity: 99.84%

Catalog No. TN1890Alias Lupeyl acetate, 3-AcetyllupeolCas No. 1617-68-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	-	In Stock
5 mg	$163	-	In Stock
10 mg	$263	-	In Stock
25 mg	$446	-	In Stock
50 mg	$645	-	In Stock
1 mL x 10 mM (in DMSO)	$193	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.84%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Lupeol acetate is a derivative of Lupeol with anti-cancer, anti-inflammatory, anti-diabetic, anti-snake venom, anti-fertility effects and oral activity. It is able to inhibit rheumatoid arthritis by down-regulating inflammatory cytokines (TNF-α, IL-1β, MCP-1, COX-2, VEGF, granzyme B) and is cytotoxic to Hep-3B and A549 cells.
In vitro	Methods: Lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and bone marrow-derived macrophages (BMDM) were treated with Lupeol acetate (0-80μM) and TNF-α, IL-1β, COX-2, and MCP-1 were measured using Western blotting. In addition, bone formation was examined using reverse transcription-PCR (RT-PCR) and tartrate-resistant acid phosphatase (TRAP) staining. Results: Lupeol acetate inhibited the activation, migration, and formation of macrophage osteoclastogenesis in a dose-dependent manner. [3]
In vivo	Methods: DBA/1J mice with collagen-induced arthritis (CIA) were randomly divided into three groups: vehicle, Lupeol acetate-treated (50mg/kg), and curcumin-treated (100mg/kg). The therapeutic effects were determined by clinical scores, expression levels of serum cytokines including TNF-α and IL-1β, (18)F-fluorodeoxyglucose ((18)F-FDG) microPET/CT, and histopathology. Results: In RA-bearing mice, the expression of inflammatory-related cytokines was suppressed, and LA improved clinical symptoms and bone erosion. Lupeol acetate also significantly reduced the accumulation of (18)F-FDG in the joints of RA-bearing mice. Lupeol acetate significantly improved the symptoms of RA by downregulating the expression of inflammatory cytokines and osteoclastogenesis. [3]
Synonyms	Lupeyl acetate, 3-Acetyllupeol

Chemical Properties

Molecular Weight	468.75
Formula	C₃₂H₅₂O₂
Cas No.	1617-68-1
Smiles	C[C@]12[C@@]([C@@]3([C@@](C)(CC1)CC[C@H]3C(C)=C)[H])(CC[C@]4([C@@]2(C)CC[C@@]5([C@]4(C)CC[C@H](OC(C)=O)C5(C)C)[H])[H])[H]
Relative Density.	1.01g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 1 mg/mL (2.13 mM), Sonication is recommended.

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.1333 mL	10.6667 mL	21.3333 mL	106.6667 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc