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Anti-NGFR/p75NTR Antibody (9I766)

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Catalog No. TMAB-09463

Anti-NGFR/p75NTR Antibody (9I766) is a Rabbit antibody targeting NGFR/p75NTR. Anti-NGFR/p75NTR Antibody (9I766) can be used in IHC-P,IHC-Fr,ICC/IF,IF.

Anti-NGFR/p75NTR Antibody (9I766)

Anti-NGFR/p75NTR Antibody (9I766)

😃Good
Catalog No. TMAB-09463
Anti-NGFR/p75NTR Antibody (9I766) is a Rabbit antibody targeting NGFR/p75NTR. Anti-NGFR/p75NTR Antibody (9I766) can be used in IHC-P,IHC-Fr,ICC/IF,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1507-10 days7-10 days
50 μL$2627-10 days7-10 days
100 μL$4727-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-NGFR/p75NTR Antibody (9I766) is a Rabbit antibody targeting NGFR/p75NTR. Anti-NGFR/p75NTR Antibody (9I766) can be used in IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG
Clone
9I766
Reactivity
Human,Rat,Mouse
Application
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:50-200; IF: 1:100-500
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationMembrane; Single-pass type I membrane protein.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells. NGF is important for the development, differentiation and survival of a variety of neuronal and non-neuronal cells. Its action is mediated by binding to two distinct receptors, the high affinity p140 and low affinity p75. p75NGFR binds neurotrophins including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5, and NT-6. p75NGFR belongs to the TNF-R superfamily and is reported to mediate NGF-induced apoptosis.
Antigen Details
Immunogen
A synthesized peptide: human p75 NTR
Antigen Species
Human
Gene Name
NGFR
Gene ID
Protein Name
Tumor necrosis factor receptor superfamily member 16
Uniprot ID
Function
Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
Chemical Properties
Molecular WeightTheoretical: 44 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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