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Ramosetron hydrochloride

Name: Ramosetron hydrochloride
Brand: TargetMol
SKU: T4562L
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4562LCas No. 132907-72-3

Alias YM-060, YM060, YM 060

Ramosetron hydrochloride (YM-060) is a serotonin 5-HT3 receptor antagonist. It is used to treat diarrhea-predominant irritable bowel syndrome and nausea.

Ramosetron hydrochloride

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Purity: 99.95%

Catalog No. T4562LAlias YM-060, YM060, YM 060Cas No. 132907-72-3

Ramosetron hydrochloride (YM-060) is a serotonin 5-HT3 receptor antagonist. It is used to treat diarrhea-predominant irritable bowel syndrome and nausea.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$32	In Stock	In Stock
10 mg	$43	In Stock	In Stock
25 mg	$71	In Stock	In Stock
50 mg	$101	In Stock	In Stock
100 mg	$179	In Stock	In Stock
200 mg	$269	-	In Stock
1 mL x 10 mM (in DMSO)	$42	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.95%

Appearance:Solid

Color:White

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COA HNMR HPLC LCMS

Product Introduction

Ramosetron hydrochloride AI Summary

Ramosetron hydrochloride shows bioactivity by blocking the entry of the Ebola virus and demonstrates antiviral properties against SARS-CoV-2. It exhibits an inhibition rate of 0.04% in VERO-6 cells and a -8.21% inhibition in Caco-2 cells after 48 hours at a 10 µM concentration. Moreover, the compound shows a 15.83% inhibition at 20 µM on the SARS-CoV-2 3CL-Pro protease, which is crucial for viral replication. Despite these activities, Ramosetron hydrochloride shows lower overall efficacy in inhibiting cell viability of SARS-CoV-2 infected Vero E6 cells compared to the arbidol control, with an inhibition index of 0.3088..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ramosetron hydrochloride (YM-060) is a serotonin 5-HT3 receptor antagonist. It is used to treat diarrhea-predominant irritable bowel syndrome and nausea.
Synonyms	YM-060, YM060, YM 060

Chemical Properties

Molecular Weight	315.8
Formula	C₁₇H₁₈ClN₃O
Cas No.	132907-72-3
Smiles	O=C(C1=CN(C)C2=C1C=CC=C2)[C@@H](C3)CCC4=C3NC=N4.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 111.1 mg/mL (351.8 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1666 mL	15.8328 mL	31.6656 mL	158.3281 mL
5 mM	0.6333 mL	3.1666 mL	6.3331 mL	31.6656 mL
10 mM	0.3167 mL	1.5833 mL	3.1666 mL	15.8328 mL
20 mM	0.1583 mL	0.7916 mL	1.5833 mL	7.9164 mL
50 mM	0.0633 mL	0.3167 mL	0.6333 mL	3.1666 mL
100 mM	0.0317 mL	0.1583 mL	0.3167 mL	1.5833 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc