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Anti-Tissue Factor Antibody-PE (2C735)
🥰Excellent
Catalog No. TMAY-02497P
Anti-Tissue Factor Antibody-PE (2C735) is a PE-conjugated Mouse antibody targeting Tissue Factor. Anti-Tissue Factor Antibody-PE (2C735) can be used in FCM.
Anti-Tissue Factor Antibody-PE (2C735)
Anti-Tissue Factor Antibody-PE (2C735)
🥰Excellent
Catalog No. TMAY-02497P
Anti-Tissue Factor Antibody-PE (2C735) is a PE-conjugated Mouse antibody targeting Tissue Factor. Anti-Tissue Factor Antibody-PE (2C735) can be used in FCM.
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Product Introduction
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Chemical Properties
| Description | Anti-Tissue Factor Antibody-PE (2C735) is a PE-conjugated Mouse antibody targeting Tissue Factor. Anti-Tissue Factor Antibody-PE (2C735) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2a |
| Clone | 2C735 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of F3 (CD142) expression on human A431 cells. |
| Application | FCM |
| Recommended Dose | 1 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human F3 / Tissue factor / CD142 (rh F3 / Tissue factor / CD142; TMPY-02530; P13726; Met 1-Glu 251) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Tissue factor is not only the main physiological initiator of normal blood coagulation, but is also important in the natural history of solid malignancies in that it potentiates metastasis and angiogenesis and mediates outside-in signalling. Tissue factor is expressed constitutively by many tissues which are not in contact with blood and by other cells upon injury or activation; the latter include endothelial cells, tissue macrophages, and peripheral blood monocytes. Coagulation Factor III is a transmembrane glycoprotein that localizes the coagulation serine protease factor VII/VIIa (FVII/VIIa) to the cell surface. The primary function of TF is to activate the clotting cascade. The TF:FVIIa complex also activates cells by cleavage of a G-protein coupled receptor called protease-activated receptor 2 (PAR2). TF is expressed by tumor cells and contributes to a variety of pathologic processes, such as thrombosis, metastasis, tumor growth, and tumor angiogenesis. As a key regulator of haemostasis and angiogenesis, it is also involved in the pathology of several diseases, including cardiovascular, inflammatory and neoplastic conditions. |
| Conjucates | PE |
| Others Formats | Unconjugated/APC/FITC |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human F3 / Tissue factor / CD142 protein (TMPY-02530) |
| Antigen Species | Human |
| Biology Area | Serine Proteases and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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