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AZD9977

Name: AZD9977
Brand: TargetMol
SKU: T9022
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9022Cas No. 1850385-64-6

Alias AZD 9977

AZD9977 is a novel, selective modulator of mineralocorticoid receptor .

AZD9977

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Purity: 99.82%

Catalog No. T9022Alias AZD 9977Cas No. 1850385-64-6

AZD9977 is a novel, selective modulator of mineralocorticoid receptor .

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
5 mg	$74	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$223	In Stock	In Stock
50 mg	$337	In Stock	In Stock
100 mg	$457	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$81	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

AZD9977 AI Summary

AZD9977 exhibits bioactivity through its interaction with the mineralocorticoid receptor, acting as an antagonist in both human and rat models. This interaction is demonstrated by its ability to inhibit receptor functions and affect the nuclear translocation of the receptor in human cells. In binding assays Test A1 and Test A2, the compound displayed IC50 values of 130.0 nM and 240.0 nM, respectively, indicating significant binding affinity. Furthermore, AZD9977 has notable pharmacokinetic properties, including oral bioavailability, clearance rates in rat models, and permeability in human cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	AZD9977 is a novel, selective modulator of mineralocorticoid receptor .
Synonyms	AZD 9977

Chemical Properties

Molecular Weight	399.37
Formula	C₂₀H₁₈FN₃O₅
Cas No.	1850385-64-6
Smiles	CNC(=O)C[C@H]1COc2cc(F)ccc2N1C(=O)c1ccc2OCC(=O)Nc2c1
Relative Density.	1.377 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (68.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (5.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5039 mL	12.5197 mL	25.0394 mL	125.1972 mL
5 mM	0.5008 mL	2.5039 mL	5.0079 mL	25.0394 mL
10 mM	0.2504 mL	1.2520 mL	2.5039 mL	12.5197 mL
20 mM	0.1252 mL	0.6260 mL	1.2520 mL	6.2599 mL
50 mM	0.0501 mL	0.2504 mL	0.5008 mL	2.5039 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc