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Anti-ATG5/APG5L Antibody (2C611)
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Catalog No. TMAB-02925
Anti-ATG5/APG5L Antibody (2C611) is a Mouse antibody targeting ATG5/APG5L. Anti-ATG5/APG5L Antibody (2C611) can be used in WB,IHC-P,IHC-Fr,IF.
Anti-ATG5/APG5L Antibody (2C611)
Anti-ATG5/APG5L Antibody (2C611)
Copy Product Info😃Good
Catalog No. TMAB-02925
Anti-ATG5/APG5L Antibody (2C611) is a Mouse antibody targeting ATG5/APG5L. Anti-ATG5/APG5L Antibody (2C611) can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-ATG5/APG5L Antibody (2C611) is a Mouse antibody targeting ATG5/APG5L. Anti-ATG5/APG5L Antibody (2C611) can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Clone | 2C611 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Paraformaldehyde-fixed, paraffin embedded (rat kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (ATG5/APG5L) Polyclonal Antibody, Unconjugated (TMAB-02925) at 1: 200 overnight at 4°C, followed by a conjugated Goat Anti-mouse IgG antibody for 90 minutes, and DAPI for nuclei staining. 2. Paraformaldehyde-fixed, paraffin embedded (mouse kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (ATG5/APG5L) Polyclonal Antibody, Unconjugated (TMAB-02925) at 1: 200 overnight at 4°C, followed by a conjugated Goat Anti-mouse IgG antibody for 90 minutes, and DAPI for nuclei staining. 3. Sample: Lane 1: Human PANC-1 cell lysates Lane 2: Human MCF-7 cell lysates Primary: Anti-ATG5/APG5L (TMAB-02925) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 32 kDa Observed band size: 47 kDa |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Cytoplasm. Note=Colocalizes with nonmuscle actin. |
| Tissue Specificity | Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | In yeast, autophagy is an essential process for survival during nutrient starvation and cell differentiation. The process of autophagy is characterized as a non-selective degradation of cytoplasmic proteins into membrane stuctures called autophagosomes, and it is dependent on several proteins, including the autophagy proteins APG5 and APG7. Yeast Apg7 and the human homolog, APG7, share similarities with the ubiquitin-activating enzyme E1 in Saccharomyces cerevisiae and are likewise responsible for enzymatically activating the autophagy conjugation system. Apg5 and the human homolog, APG5 (also designated apoptosis-specific protein or APS), function as substrates for the autophagy protein Apg12. These proteins are covalently bonded together to form Apg12/APG5 conjugates, which are required for the progression of autophagy. |
| Immunogen | Recombinant Protein: human ATG5 Protein |
| Antigen Species | Human |
| Gene Name | ATG5 |
| Gene ID | |
| Protein Name | Autophagy protein 5 |
| Uniprot ID | |
| Function | Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity).
May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. |
| Molecular Weight | Theoretical: 32 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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