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Benzyl cinnamate

Name: Benzyl cinnamate
Brand: TargetMol
SKU: T8145
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8145Cas No. 103-41-3

Alias Cinnamic acid benzyl ester, Cinnamein, Benzylcinnamoate, Benzyl 3-phenylpropenoate

Benzyl cinnamate (Benzylcinnamoate) is a natural product isolated from various plant species,with anti-inflammatory activity.

Benzyl cinnamate

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Purity: 99.77%

Catalog No. T8145Alias Cinnamic acid benzyl ester, Cinnamein, Benzylcinnamoate, Benzyl 3-phenylpropenoateCas No. 103-41-3

Benzyl cinnamate (Benzylcinnamoate) is a natural product isolated from various plant species,with anti-inflammatory activity.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$30	-	In Stock
1 g	$44	-	In Stock
5 g	$98	-	In Stock
10 g	$148	-	In Stock
1 mL x 10 mM (in DMSO)	$35	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.77%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Benzyl cinnamate AI Summary

Benzyl cinnamate exhibits a diverse range of bioactivities, demonstrating substantial potential for therapeutic and pesticidal applications. It shows inhibitory activity against 17 beta-hydroxysteroid dehydrogenase-catalyzed reactions, with IC50 values of 700.0 nM and 7000.0 nM for oxidation and reduction, respectively. Additionally, this compound functions as an antagonist on the HA-tagged mouse AT1a angiotensin 2 receptor in HEK293T cells, decreasing angiotensin 2-induced intracellular calcium uptake with an IC50 value of 47.2 µg/mL. In terms of pesticidal properties, Benzyl cinnamate is effective against Dermatophagoides pteronyssinus, showcasing an EC50 value of 0.18 g/m² after 24 hours. It also displays cytotoxic activity against human PANC1 cells under nutrient-deprived conditions with a PC50 value greater than 100.0 µM. Furthermore, the compound demonstrates inhibitory activity towards Histone Lysine Methyltransferase G9a with a potency of 31622.8 nM, and acts as a delayed death inhibitor of the malarial parasite plastid with a potency of 19011.5 nM. It also inhibits USP1/UAF1 with a potency of 10000.0 nM, and affects NPC function in a biochemical firefly luciferase enzyme assay with a potency of 14381.8 nM. Benzyl cinnamate exhibits anti-inflammatory effects by inhibiting TNF-alpha-induced ICAM1 protein expression in HUVEC cells, with a 50% inhibition in the first assay and an IC50 value of 70.0 µg/mL in a second assay. It is also cytotoxic to HUVEC cells, maintaining around 95% cell viability at a maximum tolerated dose of 70.0 µg/mL..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Benzyl cinnamate (Benzylcinnamoate) is a natural product isolated from various plant species,with anti-inflammatory activity.
Synonyms	Cinnamic acid benzyl ester, Cinnamein, Benzylcinnamoate, Benzyl 3-phenylpropenoate

Chemical Properties

Molecular Weight	238.28
Formula	C₁₆H₁₄O₂
Cas No.	103-41-3
Smiles	C(=CC(OCC1=CC=CC=C1)=O)C2=CC=CC=C2
Relative Density.	1.183. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (209.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.39 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1967 mL	20.9837 mL	41.9674 mL	209.8372 mL
5 mM	0.8393 mL	4.1967 mL	8.3935 mL	41.9674 mL
10 mM	0.4197 mL	2.0984 mL	4.1967 mL	20.9837 mL
20 mM	0.2098 mL	1.0492 mL	2.0984 mL	10.4919 mL
50 mM	0.0839 mL	0.4197 mL	0.8393 mL	4.1967 mL
100 mM	0.0420 mL	0.2098 mL	0.4197 mL	2.0984 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc