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Anti-Caspase-9 Polyclonal Antibody
(Synonyms: RNCASP9, OTTHUMP00000044594, MCH6, MCH 6, ICE like apoptotic protease 6, ICE LAP6, Caspase-9 subunit p35, Caspase9, Caspase 9c, Caspase 9 precursor, Caspase 9 apoptosis related cysteine protease, Caspase 9, CASP9, CASP 9, Apoptotic protease MCH6, Apoptotic protease MCH 6, Apoptotic protease activating factor 3, Apoptosis related cysteine peptidase, APAF3, APAF 3) Copy Product Info
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Synonyms: RNCASP9, OTTHUMP00000044594, MCH6, MCH 6, ICE like apoptotic protease 6, ICE LAP6, Caspase-9 subunit p35, Caspase9, Caspase 9c, Caspase 9 precursor, Caspase 9 apoptosis related cysteine protease, Caspase 9, CASP9, CASP 9, Apoptotic protease MCH6, Apoptotic protease MCH 6, Apoptotic protease activating factor 3, Apoptosis related cysteine peptidase, APAF3, APAF 3
Catalog No. TMAB-00292 Copy Product Info
🥰Excellent
Anti-Caspase-9 Polyclonal Antibody is a Rabbit antibody targeting Caspase-9. Anti-Caspase-9 Polyclonal Antibody can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, WB.
Anti-Caspase-9 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-Caspase-9 Polyclonal Antibody is a Rabbit antibody targeting Caspase-9. Anti-Caspase-9 Polyclonal Antibody can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, WB. |
| Synonyms | RNCASP9, OTTHUMP00000044594, MCH6, MCH 6, ICE like apoptotic protease 6, ICE LAP6, Caspase-9 subunit p35, Caspase9, Caspase 9c, Caspase 9 precursor, Caspase 9 apoptosis related cysteine protease, Caspase 9, CASP9, CASP 9, Apoptotic protease MCH6, Apoptotic protease MCH 6, Apoptotic protease activating factor 3, Apoptosis related cysteine peptidase, APAF3, APAF 3 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Dog,Cow) |
| Application | |
| Recommended Dose | FCM=1 μg/Test; ICC/IF=1:100-500; IF=1:100-500; IHC-Fr=1:100-500; IHC-P=1:100-500; WB=1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Tissue Specificity | Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Caspase 9 (also known as ICE like apoptotic protease 6 (ICE LAP6), apoptotic protease Mch6, and apoptotic protease activating factor 3 (Apaf3)) is a member of the peptidase family C14 that contains a CARD domain. This caspase is active as a heterotetramer and has been reported to have two isoforms. ProCaspase 9 has been reported to be approximately 47 kD. This caspase is present in the cytosol and, upon activation, translocates to the mitochondria. Caspase 9 is involved in the caspase activation cascade responsible for apoptosis execution and cleaves/activates Caspase 3 and Caspase 6. Caspase 9 is inhibited by the dominant negative isoform, BclXL, cIAP1, cIAP2, XIAP, and Livin. This caspase becomes activated when recruited to Apaf1/cytochrome c complex, and following cleavage by Apaf1, granzyme B, Caspase 3, possibly Caspase 8 and Caspase 10 into large p37 and small p10 subunits. Caspase 9 intereacts with BIRC7 and has been shown to cleave PARP and vimentin. |
| Immunogen | KLH conjugated synthetic peptide: human Caspase-9 subunit p35 |
| Antigen Species | Human |
| Gene Name | CASP9 |
| Gene ID | |
| Protein Name | Caspase-9 |
| Uniprot ID | |
| Biology Area | Caspases,Cytochrome C,Metabolism,Caspases,Cytochrome C,Caspases,Apoptosis |
| Function | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. |
| Molecular Weight | Theoretical: 35/50 kDa. Actual: 52 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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