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Briobacept (Synonyms: BR 3FC)
Catalog No. T77906 Copy Product Info
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Briobacept (BR 3FC), a selective human monoclonal antibody, targets BLyS (BAFF) to induce B-cell apoptosis and is a recombinant glycoprotein comprising two BLyS receptor (BR3) molecules fused to the Fc domain of human IgG1. It has applications in the study of rheumatoid arthritis (RA) [1] [2].
Briobacept
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Catalog No. T77906
Synonyms BR 3FC
Briobacept (BR 3FC), a selective human monoclonal antibody, targets BLyS (BAFF) to induce B-cell apoptosis and is a recombinant glycoprotein comprising two BLyS receptor (BR3) molecules fused to the Fc domain of human IgG1. It has applications in the study of rheumatoid arthritis (RA) [1] [2].
Briobacept
Cas No. 869881-54-9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Briobacept (BR 3FC), a selective human monoclonal antibody, targets BLyS (BAFF) to induce B-cell apoptosis and is a recombinant glycoprotein comprising two BLyS receptor (BR3) molecules fused to the Fc domain of human IgG1. It has applications in the study of rheumatoid arthritis (RA) [1] [2]. |
| In vitro | Briobacept inhibits B cell activation and induces apoptosis by blocking circulating BLyS [3]. |
| In vivo | Briobacept, administered intraperitoneally at a dose of 100 µg/mouse for five consecutive days, suppresses basal NF-κB2 activity in wild-type mice [4]. Additionally, when given thrice weekly for a duration of five weeks, briobacept impedes p52 generation and the progression of spontaneous lupus-like disease in NZB/WF1 mice [4]. |
| Synonyms | BR 3FC |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Target | BAFF |
| Cas No. | 869881-54-9 |
| Storage | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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