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Anti-Phospho-MLKL (Ser358) Antibody (4T982)

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Catalog No. TMAB-01455

Anti-Phospho-MLKL (Ser358) Antibody (4T982) is a Mouse antibody targeting Phospho-MLKL (Ser358). Anti-Phospho-MLKL (Ser358) Antibody (4T982) can be used in IHC-P,IHC-Fr,ICC/IF,IF.

Anti-Phospho-MLKL (Ser358) Antibody (4T982)

Anti-Phospho-MLKL (Ser358) Antibody (4T982)

😃Good
Catalog No. TMAB-01455
Anti-Phospho-MLKL (Ser358) Antibody (4T982) is a Mouse antibody targeting Phospho-MLKL (Ser358). Anti-Phospho-MLKL (Ser358) Antibody (4T982) can be used in IHC-P,IHC-Fr,ICC/IF,IF.
Pack SizePriceAvailabilityQuantity
50 μL$221 7-10 days
100 μL$373 7-10 days
200 μL$529 7-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-MLKL (Ser358) Antibody (4T982) is a Mouse antibody targeting Phospho-MLKL (Ser358). Anti-Phospho-MLKL (Ser358) Antibody (4T982) can be used in IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG
Clone
4T982
Reactivity
(predicted:Human)
Application
IHC-P,IHC-Fr,ICC/IF,IF
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationCytoplasm. Cell membrane. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Research BackgroundThis gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015].
Antigen Details
Immunogen
KLH conjugated Synthesised monomethylpeptide: human MLKL around the phosphorylation site of Ser358
Antigen Species
Human
Gene ID
Uniprot ID
Biology Area
Necroptosis,SARS Coronavirus,Other Kinases
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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