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Anti-Phospho-MLKL (Ser358) Antibody (4T982) is a Mouse antibody targeting Phospho-MLKL (Ser358). Anti-Phospho-MLKL (Ser358) Antibody (4T982) can be used in IHC-P,IHC-Fr,ICC/IF,IF.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $221 | 7-10 days | |
100 μL | $373 | 7-10 days | |
200 μL | $529 | 7-10 days |
Description | Anti-Phospho-MLKL (Ser358) Antibody (4T982) is a Mouse antibody targeting Phospho-MLKL (Ser358). Anti-Phospho-MLKL (Ser358) Antibody (4T982) can be used in IHC-P,IHC-Fr,ICC/IF,IF. |
Ig Type | IgG |
Clone | 4T982 |
Reactivity | (predicted:Human) |
Application | IHC-P,IHC-Fr,ICC/IF,IF |
Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500 |
Antibody Type | Monoclonal |
Host Species | Mouse |
Subcellular Localization | Cytoplasm. Cell membrane. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction. |
Construction | Hybridoma Monoclonal Antibody |
Purification | Protein G purified |
Appearance | Liquid |
Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Research Background | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]. |
Immunogen | KLH conjugated Synthesised monomethylpeptide: human MLKL around the phosphorylation site of Ser358 |
Antigen Species | Human |
Gene ID | |
Uniprot ID | |
Biology Area | Necroptosis,SARS Coronavirus,Other Kinases |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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