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Anti-IKB alpha Antibody (3W985)
😃Good
Catalog No. TMAB-07571
Anti-IKB alpha Antibody (3W985) is a Rabbit antibody targeting IKB alpha. Anti-IKB alpha Antibody (3W985) can be used in IHC-P,ICC/IF,WB,IHC-Fr,IF.
Anti-IKB alpha Antibody (3W985)
Anti-IKB alpha Antibody (3W985)
😃Good
Catalog No. TMAB-07571
Anti-IKB alpha Antibody (3W985) is a Rabbit antibody targeting IKB alpha. Anti-IKB alpha Antibody (3W985) can be used in IHC-P,ICC/IF,WB,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $148 | 7-10 days | 7-10 days | |
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $473 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-IKB alpha Antibody (3W985) is a Rabbit antibody targeting IKB alpha. Anti-IKB alpha Antibody (3W985) can be used in IHC-P,ICC/IF,WB,IHC-Fr,IF. |
| Ig Type | IgG |
| Clone | 3W985 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | IHC-P: 1:50-200; ICC/IF: 1:50-200; WB: 1:500-2000; IHC-Fr: 1:50-200; IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. |
| Tissue Specificity | Highly expressed in lymph node, thymus followed by liver, brain, muscle, kidney, gastrointestinal and reproductive tract. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | PBS (pH7.2) with 40% Glycerol, 0.05% BSA and 0.02% Proclin300. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011] |
| Immunogen | A synthesized peptide: human IkB alpha |
| Antigen Species | Human |
| Gene Name | NFKBIA |
| Gene ID | |
| Protein Name | NF-kappa-B inhibitor alpha |
| Uniprot ID | |
| Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
| Molecular Weight | Theoretical: 36 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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