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Anti-IKB alpha Antibody (3W985)
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Catalog No. TMAB-07571 Copy Product Info
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Anti-IKB alpha Antibody (3W985) is a Rabbit antibody targeting IKB alpha. Anti-IKB alpha Antibody (3W985) can be used in IHC-P,ICC/IF,WB,IHC-Fr,IF.
Anti-IKB alpha Antibody
(3W985)
(3W985)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 μL | $148 | 7-10 days | 7-10 days | |
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $473 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-IKB alpha Antibody (3W985) is a Rabbit antibody targeting IKB alpha. Anti-IKB alpha Antibody (3W985) can be used in IHC-P,ICC/IF,WB,IHC-Fr,IF. |
| Ig Type | IgG |
| Clone | 3W985 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | IHC-P: 1:50-200; ICC/IF: 1:50-200; WB: 1:500-2000; IHC-Fr: 1:50-200; IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. |
| Tissue Specificity | Highly expressed in lymph node, thymus followed by liver, brain, muscle, kidney, gastrointestinal and reproductive tract. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | PBS (pH7.2) with 40% Glycerol, 0.05% BSA and 0.02% Proclin300. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011] |
| Immunogen | A synthesized peptide: human IkB alpha |
| Antigen Species | Human |
| Gene Name | NFKBIA |
| Gene ID | |
| Protein Name | NF-kappa-B inhibitor alpha |
| Uniprot ID | |
| Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
| Molecular Weight | Theoretical: 36 kDa. Actual: 38 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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