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SPR inhibitor 3 (Synonyms: SPRi-3, SPRi3, SPRi 3)

Name: SPR inhibitor 3
Brand: TargetMol
SKU: T16924
Rating: 4.5 (1 reviews)

Catalog No. T16924 Copy Product Info

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SPR inhibitor 3 is a class of small-molecule compounds used to inhibit the activity of sepiapterin reductase; it blocks the biosynthetic pathway of tetrahydrobiopterin (BH4), thereby affecting the production of nitric oxide synthase and monoamine neurotransmitters.

SPR inhibitor 3

Copy Product Info

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Catalog No. T16924

Synonyms SPRi-3, SPRi3, SPRi 3

Cas No. 1292285-54-1

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Pack Size	Price	USA Stock	Global Stock
2 mg	$67	5 days	5 days
5 mg	$116	7-10 days	7-10 days
10 mg	$175	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$128	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	SPR inhibitor 3 is a class of small-molecule compounds used to inhibit the activity of sepiapterin reductase; it blocks the biosynthetic pathway of tetrahydrobiopterin (BH4), thereby affecting the production of nitric oxide synthase and monoamine neurotransmitters.
Targets&IC50	Sepiapterin reductase:74 nM, Biopterin:5.2 μM
In vitro	SPR inhibitor 3 (SPRi3) also significantly reduced the activity of SPR in the primary culture of mouse sensory neurons (IC50=0.45 μM), but did not affect the activity of GTP cyclohydroxylase 1 (GCH1) [1].
Synonyms	SPRi-3, SPRi3, SPRi 3

Chemical Properties

Molecular Weight	262.3
Formula	C₁₄H₁₈N₂O₃
Cas No.	1292285-54-1
Smiles	O=C(NCCC=1C=2C=C(O)C=CC2NC1C)COC
Relative Density.	1.241 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (381.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8124 mL	19.0621 mL	38.1243 mL	190.6214 mL
5 mM	0.7625 mL	3.8124 mL	7.6249 mL	38.1243 mL
10 mM	0.3812 mL	1.9062 mL	3.8124 mL	19.0621 mL
20 mM	0.1906 mL	0.9531 mL	1.9062 mL	9.5311 mL
50 mM	0.0762 mL	0.3812 mL	0.7625 mL	3.8124 mL
100 mM	0.0381 mL	0.1906 mL	0.3812 mL	1.9062 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc