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Sevabertinib

Name: Sevabertinib
Brand: TargetMol
SKU: T200964
Price: 156 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: BAY2927088, BAY 2927088) Copy Product Info

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Synonyms: BAY2927088, BAY 2927088

Catalog No. T200964 Copy Product Info

Purity: 99.81%

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Sevabertinib (BAY 2927088) is a selective, potent epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor with anti-tumor activity, used in the study of non-small cell lung cancer.

Cas No. 2521285-05-0

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Pack Size	Price	USA Stock	Global Stock
1 mg	$64	In Stock	In Stock
5 mg	$156	In Stock	In Stock
10 mg	Inquiry	In Stock	In Stock
25 mg	Inquiry	In Stock	In Stock
50 mg	Inquiry	Inquiry	Inquiry
100 mg	Inquiry	Inquiry	Inquiry
200 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.81%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Sevabertinib (BAY 2927088) is a selective, potent epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor with anti-tumor activity, used in the study of non-small cell lung cancer.
Synonyms	BAY2927088, BAY 2927088

Chemical Properties

Molecular Weight	484.93
Formula	C₂₄H₂₅ClN₄O₅
Cas No.	2521285-05-0
Smiles	N(C1=C(NC2=C1C(=O)NCC2)C=3C(OC[C@@H]4COCCO4)=CN=CC3)C5=C(OC)C(Cl)=CC=C5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 132.5 mg/mL (273.24 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: < 10 mg/mL (20.62 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (20.62 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0622 mL	10.3108 mL	20.6215 mL	103.1077 mL
5 mM	0.4124 mL	2.0622 mL	4.1243 mL	20.6215 mL
10 mM	0.2062 mL	1.0311 mL	2.0622 mL	10.3108 mL
20 mM	0.1031 mL	0.5155 mL	1.0311 mL	5.1554 mL
50 mM	0.0412 mL	0.2062 mL	0.4124 mL	2.0622 mL
100 mM	0.0206 mL	0.1031 mL	0.2062 mL	1.0311 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: Sevabertinib chemical structure | Sevabertinib formula | Sevabertinib molecular weight