Shopping Cart

Your shopping cart is currently empty

3',4'-Dimethoxyflavone

Name: 3',4'-Dimethoxyflavone
Brand: TargetMol
SKU: TN2883
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. TN2883Cas No. 4143-62-8

3',4'-Dimethoxyflavone is a standard flavonoid compound with numerous medicinal activities.

3',4'-Dimethoxyflavone

Copy Product Info

🥰Excellent

Purity: 98.05%

Catalog No. TN2883Cas No. 4143-62-8

3',4'-Dimethoxyflavone is a standard flavonoid compound with numerous medicinal activities.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$40	In Stock	In Stock
50 mg	$56	In Stock	In Stock
100 mg	$84	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$66	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.05%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

3',4'-Dimethoxyflavone AI Summary

3',4'-Dimethoxyflavone demonstrates a diverse range of bioactivities affecting multiple biological pathways and cellular processes. It notably exhibits bioactivity against Staphylococcus aureus, inhibiting its growth with a minimum inhibitory concentration (MIC) of 6.3 ug/mL in combination with subinhibitory levels of Berberine. Additionally, it shows antihistaminic activity in rat RBL2H3 cells, with an IC50 value greater than 500,000 nM for the inhibition of DNP-BSA-induced beta-hexosaminidase release. The compound also demonstrates significant bioactivity in various assays, including inhibition of enzymes and proteins such as HSD17B4, JMJD2E, Fructose-1,6-bisphosphate Aldolase, and several others associated with different pathways. It modulates activities like Enhancers of SMN2 Splice Variant Expression, Cytochrome P450 3A4 activation, and USP1/UAF1 inhibition. In AML-2/D100 cells, it shows drug resistance against vincristine with an IC50 of 1200.0 nM. Moreover, 3',4'-Dimethoxyflavone possesses antioxidant activity in rat liver microsomes (IC50 = 40.0 ug/mL), inhibits the growth of human MOLT4, MCF7, and HepG2 cells at 100 uM (though with less than 50% growth inhibition), and inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells. Cytotoxic effects are observed against mouse RAW264.7 cells (IC50 = 39680.0 nM), along with anti-inflammatory activity, inhibiting NO and PGE2 production with IC50 values of 34540.0 nM and 6460.0 nM, respectively. It also inhibits NO production by 33.31% in LPS-stimulated RAW264.7 cells and shows inhibition of CYP450 in human liver microsomes, affecting the formation of 20-HETE and EpETrE with a selectivity index of 0.08 at 10 uM concentration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

3',4'-Dimethoxyflavone is a standard flavonoid compound with numerous medicinal activities.

Chemical Properties

Molecular Weight	282.29
Formula	C₁₇H₁₄O₄
Cas No.	4143-62-8
Smiles	COc1ccc(cc1OC)-c1cc(=O)c2ccccc2o1
Relative Density.	1.242 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (194.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.08 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5425 mL	17.7123 mL	35.4246 mL	177.1228 mL
5 mM	0.7085 mL	3.5425 mL	7.0849 mL	35.4246 mL
10 mM	0.3542 mL	1.7712 mL	3.5425 mL	17.7123 mL
20 mM	0.1771 mL	0.8856 mL	1.7712 mL	8.8561 mL
50 mM	0.0708 mL	0.3542 mL	0.7085 mL	3.5425 mL
100 mM	0.0354 mL	0.1771 mL	0.3542 mL	1.7712 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc