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2,4-Dihydroxybenzoic acid

Name: 2,4-Dihydroxybenzoic acid
Brand: TargetMol
SKU: T5890
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5890Cas No. 89-86-1

2,4-Dihydroxybenzoic acid is found in alcoholic beverages.2, 4-Dihydroxybenzoic acid is a food flavour ingredient and flavour modifie.

2,4-Dihydroxybenzoic acid

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Purity: 98.99%

Catalog No. T5890Cas No. 89-86-1

2,4-Dihydroxybenzoic acid is found in alcoholic beverages.2, 4-Dihydroxybenzoic acid is a food flavour ingredient and flavour modifie.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$48	In Stock	In Stock
1 g	$70	In Stock	In Stock
5 g	$168	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.99%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

2,4-Dihydroxybenzoic acid AI Summary

2,4-Dihydroxybenzoic acid exhibits a diverse range of bioactivities across multiple biological pathways and assays, suggesting broad-spectrum potential. It inhibits the proteolytic release of C5a in activated human serum (IC50 = 22,000,000 nM), suggesting anti-inflammatory properties. Additionally, it shows significant inhibitory activity against dihydroorotate dehydrogenase 1A from Lactococcus lactis (1 µM, 91% activity), and Phenoloxidase activity in Pieris rapae (IC50 = 30,500,000 nM). 2,4-Dihydroxybenzoic acid inhibits soybean 15-lipoxygenase activity by 47.7%, human recombinant 5-lipoxygenase by 62% at 1 mM, and mouse recombinant iNOS by 16% at 1 mM. It also acts as a potent inhibitor of mushroom tyrosinase (91% at 1 mM) but weakly inhibits tyrosinase with an IC50 > 100,000 nM. Furthermore, it exhibits inhibition against various isoforms of human carbonic anhydrase with Ki values between 4900 nM and 72000 nM, and inhibits human aromatase by 93.9%. 2,4-Dihydroxybenzoic acid shows modulatory effects on lipid storage in Drosophila S3 cells, thyroid-stimulating hormone receptor activity, aldehyde dehydrogenase 1, and DNA repair processes at varying potencies. It also impacts metabolic activity and cellular ATP levels in CellTiter-Glo luminescent cell viability assays. The compound demonstrates anti-parasitic activity against Trypanosoma brucei brucei with EC50 values of 17100 nM and 19000 nM and shows moderate interaction with recombinant Trypanosoma enzymes. Additionally, 2,4-Dihydroxybenzoic acid exhibits binding affinity to CK2alpha (change in melting temperature of 3.2°C in a thermal shift assay) and inhibits the recombinant SPM-1 enzyme (76% at 1 mM). It also shows bioactivities related to hormonal signaling pathways, DNA replication, antioxidant responses, and glutaminase activity. With physico-chemical properties such as logD of -1.5, logP of 1.6, and pKa values of 4.7 and 3.1, 2,4-Dihydroxybenzoic acid presents as a compound with widely variable bioactivities affecting numerous cellular processes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

2,4-Dihydroxybenzoic acid is found in alcoholic beverages.2, 4-Dihydroxybenzoic acid is a food flavour ingredient and flavour modifie.

Chemical Properties

Molecular Weight	154.12
Formula	C₇H₆O₄
Cas No.	89-86-1
Smiles	OC(=O)C1=C(O)C=C(O)C=C1
Relative Density.	1.3725 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (129.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.4885 mL	32.4423 mL	64.8845 mL	324.4225 mL
5 mM	1.2977 mL	6.4885 mL	12.9769 mL	64.8845 mL
10 mM	0.6488 mL	3.2442 mL	6.4885 mL	32.4423 mL
20 mM	0.3244 mL	1.6221 mL	3.2442 mL	16.2211 mL
50 mM	0.1298 mL	0.6488 mL	1.2977 mL	6.4885 mL
100 mM	0.0649 mL	0.3244 mL	0.6488 mL	3.2442 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc