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Doxycycline monohydrate

Name: Doxycycline monohydrate
Brand: TargetMol
SKU: T8259
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T8259Cas No. 17086-28-1

Doxycycline monohydrate is an inhibitor of metalloproteinase (MMP)

Doxycycline monohydrate

🥰Excellent

Purity: 98.87%

Catalog No. T8259Cas No. 17086-28-1

Doxycycline monohydrate is an inhibitor of metalloproteinase (MMP)

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$42	In Stock	In Stock
100 mg	$64	In Stock	In Stock
500 mg	$103	In Stock	In Stock
1 g	$152	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:98.87%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Doxycycline monohydrate is an inhibitor of metalloproteinase (MMP)
In vivo	Doxycycline treatment inhibits the activity of tissue MMP and attenuates the decrease in the collagen content in aortas of mice haploinsufficient for collagen III, as well as prevents the development of stress-induced vessel pathology.?Doxycycline merits clinical testing as a treatment for vEDS[1].

Chemical Properties

Molecular Weight	462.4
Formula	C₂₂H₂₆N₂O₉
Cas No.	17086-28-1
Smiles	O.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c2c(O)cccc12
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (108.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1626 mL	10.8131 mL	21.6263 mL	108.1315 mL
5 mM	0.4325 mL	2.1626 mL	4.3253 mL	21.6263 mL
10 mM	0.2163 mL	1.0813 mL	2.1626 mL	10.8131 mL
20 mM	0.1081 mL	0.5407 mL	1.0813 mL	5.4066 mL
50 mM	0.0433 mL	0.2163 mL	0.4325 mL	2.1626 mL
100 mM	0.0216 mL	0.1081 mL	0.2163 mL	1.0813 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc