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Anti-Hemojuvelin Antibody (7C766)
😃Good
Catalog No. TMAY-00783
Alias hemochromatosis type 2 (juvenile)
Anti-Hemojuvelin Antibody (7C766) is a Mouse antibody targeting Hemojuvelin. Anti-Hemojuvelin Antibody (7C766) can be used in ELISA.
Anti-Hemojuvelin Antibody (7C766)
Anti-Hemojuvelin Antibody (7C766)
😃Good
Catalog No. TMAY-00783Alias hemochromatosis type 2 (juvenile)
Anti-Hemojuvelin Antibody (7C766) is a Mouse antibody targeting Hemojuvelin. Anti-Hemojuvelin Antibody (7C766) can be used in ELISA.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 μL | $198 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Hemojuvelin Antibody (7C766) is a Mouse antibody targeting Hemojuvelin. Anti-Hemojuvelin Antibody (7C766) can be used in ELISA. |
| Synonyms | hemochromatosis type 2 (juvenile) |
| Ig Type | Mouse IgG1 |
| Clone | 7C766 |
| Reactivity | Human |
| Specificity | Human Hemojuvelin |
| Application | |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Hemojuvelin / HFE2 (rh Hemojuvelin / HFE2; TMPY-02833; Q6ZVN8-1; Met1-Ser399). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Hemojuvelin, also known as HFE2, is a membrane-bound and soluble protein that belongs to the repulsive guidance molecule (RGM) family. It is known that RGMs function through Neogenin, a homolog of the Netrin receptor deleted in colon cancer. In mammals, the RGM family consists of three glycoproteins that have discrete expression patterns and functions (RGM-A, RGM-B, and RGM-C). Hemojuvelin is expressed in adult and fetal liver, heart, and skeletal muscle. Hemojuvelin acts as a bone morphogenetic protein (BMP) coreceptor. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism. It plays a key role in iron metabolism. Hemojuvelin represents the cellular receptor for hepcidin. It may be a component of the signaling pathway that activates hepcidin or it may act as a modulator of hepcidin expression. Defects in hemojuvelin are the cause of hemochromatosis type 2A, also known as juvenile hemochromatosis (JH). |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Hemojuvelin / HFE2 Protein (TMPY-02833) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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