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Anti-Hemojuvelin Antibody (7C766)

😃Good
Catalog No. TMAY-00783
Alias hemochromatosis type 2 (juvenile)

Anti-Hemojuvelin Antibody (7C766) is a Mouse antibody targeting Hemojuvelin. Anti-Hemojuvelin Antibody (7C766) can be used in ELISA.

Anti-Hemojuvelin Antibody (7C766)

Anti-Hemojuvelin Antibody (7C766)

😃Good
Catalog No. TMAY-00783Alias hemochromatosis type 2 (juvenile)
Anti-Hemojuvelin Antibody (7C766) is a Mouse antibody targeting Hemojuvelin. Anti-Hemojuvelin Antibody (7C766) can be used in ELISA.
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100 μL$198 7-10 days
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Product Introduction

Bioactivity
Description
Anti-Hemojuvelin Antibody (7C766) is a Mouse antibody targeting Hemojuvelin. Anti-Hemojuvelin Antibody (7C766) can be used in ELISA.
Aliashemochromatosis type 2 (juvenile)
Ig Type
Monoclonal Mouse IgG1
Clone
7C766
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:1000-1:2000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Hemojuvelin / HFE2 (rh Hemojuvelin / HFE2; TMPY-02833; Q6ZVN8-1; Met1-Ser399). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundHemojuvelin, also known as HFE2, is a membrane-bound and soluble protein that belongs to the repulsive guidance molecule (RGM) family. It is known that RGMs function through Neogenin, a homolog of the Netrin receptor deleted in colon cancer. In mammals, the RGM family consists of three glycoproteins that have discrete expression patterns and functions (RGM-A, RGM-B, and RGM-C). Hemojuvelin is expressed in adult and fetal liver, heart, and skeletal muscle. Hemojuvelin acts as a bone morphogenetic protein (BMP) coreceptor. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism. It plays a key role in iron metabolism. Hemojuvelin represents the cellular receptor for hepcidin. It may be a component of the signaling pathway that activates hepcidin or it may act as a modulator of hepcidin expression. Defects in hemojuvelin are the cause of hemochromatosis type 2A, also known as juvenile hemochromatosis (JH).
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human Hemojuvelin / HFE2 Protein (TMPY-02833)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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