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Chloroxine

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Catalog No. T0500Cas No. 773-76-2

Alias Capitrol

Chloroxine (Capitrol) is a synthetic quinoline derivative with antibacterial activity. Although the mechanism of action is not fully understood, topical administration of chloroxine diminishes mitotic activity in the epidermis, thereby reducing excessive scaling associated with dandruff or seborrheic dermatitis of the scalp, including psoriasis and eczema.

Chloroxine

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Purity: 99.75%

Catalog No. T0500Alias CapitrolCas No. 773-76-2

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$31	In Stock	In Stock
1 g	$40	In Stock	In Stock
5 g	$52	-	In Stock
10 g	$74	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.75%

Appearance:Solid

Color:White

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COA HPLC HNMR LCMS

Product Introduction

Chloroxine AI Summary

Chloroxine exhibits a diverse range of bioactivities targeting multiple cellular functions and pathways. It has cytotoxic effects on Streptococcus and SK(-)GAS group A Streptococcus with EC50 values of 258.0 nM and 3306.0 nM, respectively. The compound shows significant inhibitory activity against HIV-1 integrase, various lipoxygenase enzymes, and several human enzymes including HDAC6, JMJD2E, and NDM-1, VIM-1, and IMP-1 enzymatic families. It also inhibits mitochondrial division, SMN2 splice variant expression, Tau fibril formation, and more, with potency values ranging from 3981.1 nM to 70794.6 nM. In antiviral studies, Chloroxine inhibits SARS-CoV-2 induced cytotoxicity and papain-like protease with varied efficacy, showing an IC50 value of 7240.0 nM for the latter. It exhibits anti-fungal activity against Candida albicans and Cryptococcus neoformans with MIC values of 1250.0 nM and 2500.0 nM, respectively, but does not significantly affect several bacterial strains at concentrations over 10000.0 nM. The compound demonstrates binding affinities and inhibitory activities against MMP-14, MMP-9, and MMP-13, with IC50 values of 25600.0 nM, 15900.0 nM, and 19600.0 nM, respectively. Furthermore, Chloroxine inhibits the uptake of sodium fluorescein in OATP1B1 and OATP1B3-transfected CHO cells, and activates human PXR in HepG2 cells, leading to an efficacy of 107.9% compared to rifampicin. It also shows high metabolic stability in human and Sprague-Dawley rat plasma with a half-life of 67.7 hr and 18.6 hr, respectively, but a shorter half-life in liver microsomes. The compound's solubility varies with pH, being more soluble at pH 1. Overall, Chloroxine is notable for its multifaceted bioactivities, including significant antiviral, enzyme inhibitory, and anti-fungal properties, making it a promising candidate for further biomedical research..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Chloroxine (Capitrol) is a synthetic quinoline derivative with antibacterial activity. Although the mechanism of action is not fully understood, topical administration of chloroxine diminishes mitotic activity in the epidermis, thereby reducing excessive scaling associated with dandruff or seborrheic dermatitis of the scalp, including psoriasis and eczema.
Synonyms	Capitrol

Chemical Properties

Molecular Weight	214.05
Formula	C₉H₅Cl₂NO
Cas No.	773-76-2
Smiles	OC1=C(Cl)C=C(Cl)C2=CC=CN=C12
Relative Density.	1.3320 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 6.25 mg/mL (29.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6718 mL	23.3590 mL	46.7181 mL	233.5903 mL
5 mM	0.9344 mL	4.6718 mL	9.3436 mL	46.7181 mL
10 mM	0.4672 mL	2.3359 mL	4.6718 mL	23.3590 mL
20 mM	0.2336 mL	1.1680 mL	2.3359 mL	11.6795 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc