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Magnocurarine

Name: Magnocurarine
Brand: TargetMol
SKU: TN1902
Price: 251 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1902Cas No. 6801-40-7

Magnocurarine is a natural product from Magnolia officinalis.

Magnocurarine

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Purity: 99.92%

Catalog No. TN1902Cas No. 6801-40-7

Magnocurarine is a natural product from Magnolia officinalis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$251	-	In Stock
5 mg	$626	-	In Stock
10 mg	$888	-	In Stock
25 mg	$1,330	-	In Stock
50 mg	$1,790	-	In Stock
1 mL x 10 mM (in DMSO)	$653	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Magnocurarine is a natural product from Magnolia officinalis.

In vitro

The stem of Magnoliae officinalis (MO) cortex is always preliminarily processed before being applied in traditional Chinese medicine. The definite bioavailability of honokiol (HO) and magnolol (MA) in processed MO (PMO) and the effect of chemical profiling change on the pharmacokinetics of HO and MA are always a greater challenge compared with those of MO. Compared with that of MO, the pharmacokinetic profiling of HO and MA in the PMO was significantly changed and the mean Tmax of HO and MA was increased by 31 and 50% (P < 0.05), respectively; the mean AUC0-t and Cmax of HO were increased by 36 and 24% (P < 0.05), respectively. Subsequently, the chemical profiling of MO and PMO was investigated by a simple and rapid LC-Q/TOF-MS coupled with multivariate analysis method. Principal component analysis and hierarchical cluster analysis of the chromatographic data demonstrated that the chemical profiling of PMO was significantly different from that of MO. Eight marker components including six alkaloids (Magnocurarine, magnoflorine, roemerine and three unidentified peaks) and two lignans (obovatol and MA) were screened out by partial least-squares discriminant analysis.

Chemical Properties

Molecular Weight	314.4
Formula	C₁₉H₂₄NO₃
Cas No.	6801-40-7
Smiles	C([C@@H]1C=2C(=CC(OC)=C(O)C2)CC[N+]1(C)C)C3=CC=C(O)C=C3
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (174.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1807 mL	15.9033 mL	31.8066 mL	159.0331 mL
5 mM	0.6361 mL	3.1807 mL	6.3613 mL	31.8066 mL
10 mM	0.3181 mL	1.5903 mL	3.1807 mL	15.9033 mL
20 mM	0.1590 mL	0.7952 mL	1.5903 mL	7.9517 mL
50 mM	0.0636 mL	0.3181 mL	0.6361 mL	3.1807 mL
100 mM	0.0318 mL	0.1590 mL	0.3181 mL	1.5903 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc