Anti-DR6 Antibody (5R172) (Synonyms: tumor necrosis factor receptor superfamily, member 21)

Name: Anti-DR6 Antibody (5R172)
Brand: TargetMol
SKU: TMAY-00405
Rating: 4.5 (1 reviews)

Catalog No. TMAY-00405 Copy Product Info

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Anti-DR6 Antibody (5R172) is a Mouse antibody targeting DR6. Anti-DR6 Antibody (5R172) can be used in ELISA.

Anti-DR6 Antibody (5R172)

Copy Product Info

🥰Excellent

Catalog No. TMAY-00405

Synonyms tumor necrosis factor receptor superfamily, member 21

Anti-DR6 Antibody (5R172) is a Mouse antibody targeting DR6. Anti-DR6 Antibody (5R172) can be used in ELISA.

Anti-DR6 Antibody
(5R172)

Pack Size	Price	USA Stock	Global Stock	Quantity
100 μL	$198	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-DR6 Antibody (5R172) is a Mouse antibody targeting DR6. Anti-DR6 Antibody (5R172) can be used in ELISA.
Synonyms	tumor necrosis factor receptor superfamily, member 21
Ig Type	Mouse IgG1
Clone	5R172
Reactivity	Human
Specificity	Human DR6/TNFRSF21
Application	ELISA
Recommended Dose	ELISA: 1:1000-1:2000
Antibody Type	Monoclonal
Host Species	Mouse
Construction	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TNFRSF21 / DR6 (rh TNFRSF21 / DR6; TMPY-01341; NP_055267.1; Met1-Leu350). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Purification	Protein A
Appearance	Liquid
Formulation	0.2 μm filtered solution in PBS
Research Background	TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.

Related Conjugates and Formulations

Conjucates

Unconjugated

Antigen Details

Immunogen	Recombinant Protein: Human TNFRSF21 / DR6 Protein (TMPY-01341)
Antigen Species	Human

Chemical Properties

Stability & Storage

Stability & Storage	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
Transport	Shipping with blue ice.