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Anti-DR6 Antibody (5R172)
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Catalog No. TMAY-00405
Alias tumor necrosis factor receptor superfamily, member 21
Anti-DR6 Antibody (5R172) is a Mouse antibody targeting DR6. Anti-DR6 Antibody (5R172) can be used in ELISA.
Anti-DR6 Antibody (5R172)
Anti-DR6 Antibody (5R172)
😃Good
Catalog No. TMAY-00405Alias tumor necrosis factor receptor superfamily, member 21
Anti-DR6 Antibody (5R172) is a Mouse antibody targeting DR6. Anti-DR6 Antibody (5R172) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Chemical Properties
| Description | Anti-DR6 Antibody (5R172) is a Mouse antibody targeting DR6. Anti-DR6 Antibody (5R172) can be used in ELISA. |
| Alias | tumor necrosis factor receptor superfamily, member 21 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 5R172 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TNFRSF21 / DR6 (rh TNFRSF21 / DR6; TMPY-01341; NP_055267.1; Met1-Leu350). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human TNFRSF21 / DR6 Protein (TMPY-01341) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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