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Hydroxygenkwanin

Name: Hydroxygenkwanin
Brand: TargetMol
SKU: T4S0094
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4S0094Cas No. 20243-59-8

Alias Luteolin 7-methylether, 7-O-Methylluteolin

1. Hydroxygenkwanin (Luteolin 7-methylether) possesses significant the antioxidative activity . 2. Hydroxygenkwanin has cytotoxicity, may be an effective natural product to treat glioma, and the combination of Apigenin and Hydroxygenkwanin may be a promising method for glioma chemotherapy.

Hydroxygenkwanin

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Purity: 99.62%

Catalog No. T4S0094Alias Luteolin 7-methylether, 7-O-MethylluteolinCas No. 20243-59-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$93	In Stock	In Stock
25 mg	$161	In Stock	In Stock
50 mg	$240	In Stock	In Stock
100 mg	$357	In Stock	In Stock
200 mg	$527	In Stock	-
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.62%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Hydroxygenkwanin AI Summary

Hydroxygenkwanin exhibits a broad spectrum of bioactivities and cytotoxic properties. It shows significant antimicrobial activity against Porphyromonas gingivalis, Prevotella intermedia, Streptococcus mutans, and Actinomyces viscosus with MIC values ranging from 625.0 to 1250.0 µg/mL. It also demonstrates notable anti-inflammatory effects in Swiss mice, with a 78.0% inhibition of TPA-induced edema and a 6.0% inhibition of arachidonic acid-induced edema. Additionally, the compound has been found to inhibit neuraminidase activity in various strains of Influenza A virus, with IC50 values of 15.46 µg/mL, 51,500 nM, 83,900 nM, and 62,000 nM. Its antimycobacterial activity against Mycobacterium tuberculosis H37Rv is also highlighted, with the most potent MIC of 15.3 µg/mL in ethanol/methanol. Furthermore, Hydroxygenkwanin demonstrates selectivity towards MAO-B over MAO-A with a selectivity index of 58.2 and inhibits human MAO-A with an IC50 value of 51.0 nM. It shows efficacy as an alpha-glucosidase inhibitor with an IC50 value of 731100.0 nM. However, it also exhibits cytotoxicity against African green monkey Vero cells with an MNCC of 0.08 mM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Hydroxygenkwanin (Luteolin 7-methylether) possesses significant the antioxidative activity . 2. Hydroxygenkwanin has cytotoxicity, may be an effective natural product to treat glioma, and the combination of Apigenin and Hydroxygenkwanin may be a promising method for glioma chemotherapy.
Synonyms	Luteolin 7-methylether, 7-O-Methylluteolin

Chemical Properties

Molecular Weight	300.26
Formula	C₁₆H₁₂O₆
Cas No.	20243-59-8
Smiles	COc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1
Relative Density.	1.538g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (183.17 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3304 mL	16.6522 mL	33.3045 mL	166.5223 mL
5 mM	0.6661 mL	3.3304 mL	6.6609 mL	33.3045 mL
10 mM	0.3330 mL	1.6652 mL	3.3304 mL	16.6522 mL
20 mM	0.1665 mL	0.8326 mL	1.6652 mL	8.3261 mL
50 mM	0.0666 mL	0.3330 mL	0.6661 mL	3.3304 mL
100 mM	0.0333 mL	0.1665 mL	0.3330 mL	1.6652 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc