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Bifendate
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Catalog No. T3273Cas No. 73536-69-3
Alias Bifendatatum
Bifendate (Bifendatatum) is commonly used to treat the transaminase elevation that caused by viral hepatitis and drug-induced liver injury.
Bifendate
Copy Product Info🥰Excellent
Purity: 99.72%
Catalog No. T3273Alias BifendatatumCas No. 73536-69-3
Bifendate (Bifendatatum) is commonly used to treat the transaminase elevation that caused by viral hepatitis and drug-induced liver injury.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $32 | In Stock | In Stock | |
| 100 mg | $45 | In Stock | In Stock | |
| 500 mg | $98 | In Stock | In Stock | |
| 1 g | $146 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.72%
Color:White
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Product Introduction
Bifendate AI Summary
Bifendate exhibits a range of biological activities, including antiviral, anti-inflammatory, and hepatoprotective effects. Notably, it shows anti-HIV activity with an EC50 value of 5.0 µg/mL and a therapeutic index greater than 20.0. It inhibits p-glycoprotein in human K562/A02 cells, increasing the accumulation of rhodamine 123 at 10 µM. It demonstrates hepatoprotective activity in various models such as reducing serum ALT and AST levels in a mouse hepatitis model challenged with concanavalin A and providing protection against carbon tetrachloride-induced toxicity in human HL-7702 cells. In Sprague-Dawley rat models, it exhibits low intrinsic clearance on several CYP enzymes and downregulates CYP2E1 and CYP3A2 protein levels, indicating liver function protection. Additionally, Bifendate shows cytoprotective activity against H2O2-induced cell death in rat HBZY-1 cells.
It also has some degree of antiviral activity, inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells and showing SARS-CoV-2 3CL-Pro protease inhibition. Its cytotoxic effects are noted against certain cell lines, albeit with high IC50 values, indicating low potency in inhibiting cell proliferation. Bifendate demonstrates inhibition of human HDAC6 enzyme, particularly in assays using commercial peptide substrates. It does not show significant inhibition of electric eel AChE or equine serum BuChE and exhibits some hepatotoxicity in Kunming mice..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Bifendate (Bifendatatum) is commonly used to treat the transaminase elevation that caused by viral hepatitis and drug-induced liver injury. |
| Synonyms | Bifendatatum |
| Molecular Weight | 418.35 |
| Formula | C20H18O10 |
| Cas No. | 73536-69-3 |
| Smiles | C(OC)(=O)C=1C(=C2C(=C(OC)C1)OCO2)C3=C4C(=C(OC)C=C3C(OC)=O)OCO4 |
| Relative Density. | 1.39g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.19 mg/mL (10.02 mM), Sonication is recommended.  | ||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.39 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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