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Anti-CD16a Antibody (5Q617) (Synonyms: Fc fragment of IgG, low affinity IIIa, receptor (CD16a))
Catalog No. TMAY-00743 Copy Product Info
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Anti-CD16a Antibody (5Q617) is a Mouse antibody targeting CD16a. Anti-CD16a Antibody (5Q617) can be used in FCM.
Anti-CD16a Antibody (5Q617)
Copy Product Info🥰Excellent
Catalog No. TMAY-00743
Synonyms Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Anti-CD16a Antibody (5Q617) is a Mouse antibody targeting CD16a. Anti-CD16a Antibody (5Q617) can be used in FCM.
Anti-CD16a Antibody
(5Q617)
(5Q617)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 20 μL | $92 | 7-10 days | 7-10 days | |
| 100 μL | $269 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-CD16a Antibody (5Q617) is a Mouse antibody targeting CD16a. Anti-CD16a Antibody (5Q617) can be used in FCM. |
| Synonyms | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) |
| Ig Type | Mouse IgG1 |
| Clone | 5Q617 |
| Reactivity | Human |
| Specificity | Human CD16a/FCGR3A/Fc gamma RIIIA |
| Verified Activity | Flow cytometric analysis of Human CD16 expression on human whole blood lymphocyte. Cells were stained with purified anti-Human CD16, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| Application | |
| Recommended Dose | FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD16a/FCGR3A (rh CD16a/FCGR3A; TMPY-02816; P08637-1; Met1-Gln208,176F). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells. CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation. |
| Conjucates | Unconjugated |
| Others Formats | APC/PerCP/FITC/PE |
| Antibody Types Available | 5 |
| Immunogen | Recombinant Protein: Human CD16a/FCGR3A Protein (TMPY-02816) |
| Antigen Species | Human |
| Biology Area | Fc Receptors, Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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