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Anti-Factor I heavy chain Polyclonal Antibody
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Catalog No. TMAB-05787
Anti-Factor I heavy chain Polyclonal Antibody is a Rabbit antibody targeting Factor I heavy chain. Anti-Factor I heavy chain Polyclonal Antibody can be used in WB.
Anti-Factor I heavy chain Polyclonal Antibody
Anti-Factor I heavy chain Polyclonal Antibody
😃Good
Catalog No. TMAB-05787
Anti-Factor I heavy chain Polyclonal Antibody is a Rabbit antibody targeting Factor I heavy chain. Anti-Factor I heavy chain Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Factor I heavy chain Polyclonal Antibody is a Rabbit antibody targeting Factor I heavy chain. Anti-Factor I heavy chain Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted; extracellular space. |
| Tissue Specificity | Plasma. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The complement pathway is an important host defense system that contributes to both innate and acquired immunity. There are three pathways of complement activation: the classical pathway, lectin pathway and alternative pathway. Complement protein Factor I is a key serine protease that modulates the complement cascade by regulating the levels of C3 convertases. It circulates in plasma as a heavily N-glycosylated heterodimer made up of two disulfide linked chains, each carrying three N-linked oligosaccharide chains that may have both structural and functional roles in the interactions with the natural substrate and the cofactor during catalysis. Factor I is a serine protease with a high degree of specificity for C3b and C4b. It requires protein cofactors for cleavage of these complement proteins; Factor H, CR1 or MCP are required for C3b cleavage, and C4bp or CR1 are required for C4b cleavage. |
| Immunogen | KLH conjugated synthetic peptide: human Complement factor I heavy chain |
| Antigen Species | Human |
| Gene Name | CFI |
| Gene ID | |
| Protein Name | Complement factor I |
| Uniprot ID | |
| Function | Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.
Subcellular Location : Secreted; extracellular space. |
| Molecular Weight | Theoretical: 35/63 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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