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Altenusin

Name: Altenusin
Brand: TargetMol
SKU: T8895
Price: 389 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8895Cas No. 31186-12-6

Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.

Altenusin

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Purity: 99%

Catalog No. T8895Cas No. 31186-12-6

Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.

Pack Size	Price	Availability
1 mg	$389	In Stock
5 mg	$970	In Stock
10 mg	$1,289	In Stock
25 mg	$1,619	In Stock
50 mg	$2,500	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
Targets&IC50	FXR:EC50 : 3.2 ± 0.2 μM
In vitro	Treatment of primary mouse hepatocytes with altenusin inhibited oleic acid–induced steatosis in vitro [1].

Chemical Properties

Molecular Weight	290.27
Formula	C₁₅H₁₄O₆
Cas No.	31186-12-6
Smiles	C(O)(=O)C1=C(C=C(OC)C=C1O)C2=C(C)C=C(O)C(O)=C2
Relative Density.	1.431 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (172.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4451 mL	17.2253 mL	34.4507 mL	172.2534 mL
5 mM	0.6890 mL	3.4451 mL	6.8901 mL	34.4507 mL
10 mM	0.3445 mL	1.7225 mL	3.4451 mL	17.2253 mL
20 mM	0.1723 mL	0.8613 mL	1.7225 mL	8.6127 mL
50 mM	0.0689 mL	0.3445 mL	0.6890 mL	3.4451 mL
100 mM	0.0345 mL	0.1723 mL	0.3445 mL	1.7225 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc