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4-Phenoxybenzylamine
🥰Excellent
Catalog No. T5938Cas No. 107622-80-0
4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation, with an IC50 of approximately 500 μM against HCV NS3/4a.
4-Phenoxybenzylamine
🥰Excellent
Purity: 97.26%
Catalog No. T5938Cas No. 107622-80-0
4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation, with an IC50 of approximately 500 μM against HCV NS3/4a.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 200 mg | $30 | In Stock | |
| 500 mg | $45 | In Stock | |
| 1 g | $66 | In Stock | |
| 2 g | $95 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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Purity:97.26%
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Product Introduction
Bioactivity
Chemical Properties
| Description | 4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation, with an IC50 of approximately 500 μM against HCV NS3/4a. |
| Targets&IC50 | HCV NS3/4A:500 μM |
| In vitro | A novel and highly conserved binding site at the interface of the protease and helicase domains of the Hepatitis C Virus (HCV) NS3 protein has been identified. Binding of 4-Phenoxybenzylamine to this allosteric site inhibits NS3 function by stabilizing an inactive conformation, introducing a new class of direct-acting antiviral agents. |
| Molecular Weight | 199.25 |
| Formula | C13H13NO |
| Cas No. | 107622-80-0 |
| Smiles | NCC1=CC=C(OC2=CC=CC=C2)C=C1 |
| Relative Density. | 1.12 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (150.56 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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