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Dimethyl lithospermate B

Name: Dimethyl lithospermate B
Brand: TargetMol
SKU: T8299
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8299Cas No. 875313-64-7

Alias dmLSB

Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.

Dimethyl lithospermate B

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Purity: 99.62%

Catalog No. T8299Alias dmLSBCas No. 875313-64-7

Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$147	In Stock	In Stock
2 mg	$225	In Stock	In Stock
5 mg	$396	In Stock	In Stock
10 mg	$579	In Stock	In Stock
25 mg	$912	In Stock	In Stock
50 mg	$1,220	-	In Stock
100 mg	$1,650	-	In Stock
200 mg	$2,230	-	In Stock
1 mL x 10 mM (in DMSO)	$558	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.62%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.
In vitro	Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to the increased inward current during the early phases of the action potential [1][2].
Synonyms	dmLSB

Chemical Properties

Molecular Weight	746.67
Formula	C₃₈H₃₄O₁₆
Cas No.	875313-64-7
Smiles	COC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c2O[C@@H]([C@@H](C(=O)O[C@H](Cc3ccc(O)c(O)c3)C(=O)OC)c12)c1ccc(O)c(O)c1
Relative Density.	1.525 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 132.5 mg/mL (177.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3393 mL	6.6964 mL	13.3928 mL	66.9640 mL
5 mM	0.2679 mL	1.3393 mL	2.6786 mL	13.3928 mL
10 mM	0.1339 mL	0.6696 mL	1.3393 mL	6.6964 mL
20 mM	0.0670 mL	0.3348 mL	0.6696 mL	3.3482 mL
50 mM	0.0268 mL	0.1339 mL	0.2679 mL	1.3393 mL
100 mM	0.0134 mL	0.0670 mL	0.1339 mL	0.6696 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc