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Dimethyl lithospermate B

🥰Excellent
Catalog No. T8299Cas No. 875313-64-7
Alias dmLSB

Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.

Dimethyl lithospermate B

Dimethyl lithospermate B

🥰Excellent
Purity: 99.62%
Catalog No. T8299Alias dmLSBCas No. 875313-64-7
Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$147In StockIn Stock
2 mg$225In StockIn Stock
5 mg$396In StockIn Stock
10 mg$579In StockIn Stock
25 mg$912In StockIn Stock
50 mg$1,220-In Stock
100 mg$1,650-In Stock
200 mg$2,230-In Stock
1 mL x 10 mM (in DMSO)$558In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.62%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.
In vitro
Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to the increased inward current during the early phases of the action potential [1][2].
SynonymsdmLSB
Chemical Properties
Molecular Weight746.67
FormulaC38H34O16
Cas No.875313-64-7
SmilesCOC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c2O[C@@H]([C@@H](C(=O)O[C@H](Cc3ccc(O)c(O)c3)C(=O)OC)c12)c1ccc(O)c(O)c1
Relative Density.1.525 g/cm3 (Predicted)
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 132.5 mg/mL (177.45 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.3393 mL6.6964 mL13.3928 mL66.9640 mL
5 mM0.2679 mL1.3393 mL2.6786 mL13.3928 mL
10 mM0.1339 mL0.6696 mL1.3393 mL6.6964 mL
20 mM0.0670 mL0.3348 mL0.6696 mL3.3482 mL
50 mM0.0268 mL0.1339 mL0.2679 mL1.3393 mL
100 mM0.0134 mL0.0670 mL0.1339 mL0.6696 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SodiumChannelSodium ChannelNa+ channelsNa channelsInhibitorinhibitDimethyl lithospermate B
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