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Dimethyl lithospermate B

Name: Dimethyl lithospermate B
Brand: TargetMol
SKU: T8299
Price: 155 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T8299Cas No. 875313-64-7

Alias dmLSB

Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.

Dimethyl lithospermate B

🥰Excellent

Purity: 99.62%

Catalog No. T8299Alias dmLSBCas No. 875313-64-7

Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.

Pack Size	Price	Availability
1 mg	$155	In Stock
5 mg	$416	In Stock
10 mg	$593	In Stock
25 mg	$946	In Stock
50 mg	$1,270	In Stock
100 mg	$1,690	In Stock
200 mg	$2,290	In Stock
1 mL x 10 mM (in DMSO)	$579	In Stock

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Batch Information

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Purity:99.62%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.
In vitro	Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to the increased inward current during the early phases of the action potential [1][2].
Synonyms	dmLSB

Chemical Properties

Molecular Weight	746.67
Formula	C₃₈H₃₄O₁₆
Cas No.	875313-64-7
Smiles	COC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c2O[C@@H]([C@@H](C(=O)O[C@H](Cc3ccc(O)c(O)c3)C(=O)OC)c12)c1ccc(O)c(O)c1
Relative Density.	1.525 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (30.13 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3393 mL	6.6964 mL	13.3928 mL	66.9640 mL
5 mM	0.2679 mL	1.3393 mL	2.6786 mL	13.3928 mL
10 mM	0.1339 mL	0.6696 mL	1.3393 mL	6.6964 mL
20 mM	0.0670 mL	0.3348 mL	0.6696 mL	3.3482 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc