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Cromoglicic acid

Name: Cromoglicic acid
Brand: TargetMol
SKU: T8239
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8239Cas No. 16110-51-3

Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells.

Cromoglicic acid

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Purity: 99.55%

Catalog No. T8239Cas No. 16110-51-3

Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$64	In Stock	In Stock
50 mg	$98	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.55%

Color:White

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Cromoglicic acid AI Summary

Cromoglicic acid is a compound with multifaceted bioactivities and properties, showcasing potential in various biological contexts. It has a binding constant of Log K' = 1.07 against human serum albumin (HSA), suggesting its ability to bind and be transported by this protein in the body. It is highly acidic with pKa values below 2.0 and exhibits a dissociation constant (pKa) of 1.9. In human pharmacokinetics, it demonstrates a fraction unbound in plasma logFu of 0.0 and a volume of distribution at steady state (Vdss) of 0.32 L.kg-1, with an unbound Cmax of 0.192 µM. Cromoglicic acid also displays bioactivities as an inhibitor of: - Lamin A splicing (potency: 707.9 nM). - Tyrosyl-DNA Phosphodiesterase (TDP1) (potency: 1778.3 nM). - Various viral activities, including Marburg Virus, Lassa Virus, and SARS-CoV-2, although with varying potencies for each virus. - Plasmodium falciparum proliferation (potency ranging from 0.7 to 37.6 nM). - Human Apurinic/apyrimidinic Endonuclease 1 (APE1) (potency: 631.0 nM). In addition to these bioactivities, Cromoglicic acid acts as an agonist at human GPR35, showing EC50 values in various assays, such as 210.0 nM in Ca+2 release and 520.0 nM in DMR assays. It exhibits a competitive binding affinity to Nluc-fused human GPR35 with a Ki value of 2970.0 nM. Regarding safety and absorption, Cromoglicic acid has a hepatic side effect (HepSE) score of 1.0, indicating a risk for liver disease, without observable acute hepatotoxicity. It is moderately absorbed in the human intestine with a log10(%HIA) of approximately 1.021 and shows minimal inhibition of the Bile Salt Export Pump (BSEP), with an IC50 value greater than 1,000,000 nM. Cromoglicic acid also impacts various biological parameters, influencing liver enzymes, kidney function markers, electrolytes, cholesterol levels, and blood cell parameters, suggesting potential influences on liver, kidney, cardiovascular, and hematological functions. Overall, Cromoglicic acid presents as a molecule with significant acid-base properties, diverse bioactivities including antiviral, antiparasitic, enzymatic inhibition, and receptor agonism, and some potential for liver-related side effects..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells.

Chemical Properties

Molecular Weight	468.37
Formula	C₂₃H₁₆O₁₁
Cas No.	16110-51-3
Smiles	OC(COc1cccc2oc(cc(=O)c12)C(O)=O)COc1cccc2oc(cc(=O)c12)C(O)=O
Relative Density.	1.623

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20.8 mg/mL (44.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1351 mL	10.6753 mL	21.3506 mL	106.7532 mL
5 mM	0.4270 mL	2.1351 mL	4.2701 mL	21.3506 mL
10 mM	0.2135 mL	1.0675 mL	2.1351 mL	10.6753 mL
20 mM	0.1068 mL	0.5338 mL	1.0675 mL	5.3377 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc