Shopping Cart

Remove All
Your shopping cart is currently empty

GET73

Name: GET73
Brand: TargetMol
SKU: T11393
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11393Cas No. 202402-01-5

Alias GET 73, Gamma hydroxybutyric acid analogue

GET73 (Gamma hydroxybutyric acid analogue) is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties.

GET73

🥰Excellent

Purity: 99.54%

Catalog No. T11393Alias GET 73, Gamma hydroxybutyric acid analogueCas No. 202402-01-5

GET73 (Gamma hydroxybutyric acid analogue) is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties.

Pack Size	Price	Availability
5 mg	$35	In Stock
10 mg	$54	In Stock
25 mg	$112	In Stock
50 mg	$169	In Stock
100 mg	$255	In Stock
200 mg	$378	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.54%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	GET73 (Gamma hydroxybutyric acid analogue) is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties.
In vitro	GET73 (1 μM, 10 μM; 1 hour) 1 hour before and during chronic ethanol exposure prevents ethanol-induced a reduction of cell viability, an alteration of cytoskeleton, an increase of reactive oxygen species production and a decrease in extracellular glutamate levels.
In vivo	GET73 exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test.
Synonyms	GET 73, Gamma hydroxybutyric acid analogue

Chemical Properties

Molecular Weight	275.27
Formula	C₁₃H₁₆F₃NO₂
Cas No.	202402-01-5
Smiles	COCCCC(=O)NCc1ccc(cc1)C(F)(F)F
Relative Density.	1.175 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 97 mg/mL (352.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6328 mL	18.1640 mL	36.3280 mL	181.6398 mL
5 mM	0.7266 mL	3.6328 mL	7.2656 mL	36.3280 mL
10 mM	0.3633 mL	1.8164 mL	3.6328 mL	18.1640 mL
20 mM	0.1816 mL	0.9082 mL	1.8164 mL	9.0820 mL
50 mM	0.0727 mL	0.3633 mL	0.7266 mL	3.6328 mL
100 mM	0.0363 mL	0.1816 mL	0.3633 mL	1.8164 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc