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GET73

Name: GET73
Brand: TargetMol
SKU: T11393
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11393Cas No. 202402-01-5

Alias GET 73, Gamma hydroxybutyric acid analogue

GET73 (Gamma hydroxybutyric acid analogue) is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties.

GET73

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Purity: 99.54%

Catalog No. T11393Alias GET 73, Gamma hydroxybutyric acid analogueCas No. 202402-01-5

GET73 (Gamma hydroxybutyric acid analogue) is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$35	In Stock	In Stock
10 mg	$54	In Stock	In Stock
25 mg	$112	In Stock	In Stock
50 mg	$169	In Stock	In Stock
100 mg	$255	In Stock	In Stock
200 mg	$378	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.54%

Appearance:solid

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	GET73 (Gamma hydroxybutyric acid analogue) is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties.
In vitro	GET73 (1 μM, 10 μM; 1 hour) 1 hour before and during chronic ethanol exposure prevents ethanol-induced a reduction of cell viability, an alteration of cytoskeleton, an increase of reactive oxygen species production and a decrease in extracellular glutamate levels.
In vivo	GET73 exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test.
Synonyms	GET 73, Gamma hydroxybutyric acid analogue

Chemical Properties

Molecular Weight	275.27
Formula	C₁₃H₁₆F₃NO₂
Cas No.	202402-01-5
Smiles	COCCCC(=O)NCc1ccc(cc1)C(F)(F)F
Relative Density.	1.175 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 97 mg/mL (352.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6328 mL	18.1640 mL	36.3280 mL	181.6398 mL
5 mM	0.7266 mL	3.6328 mL	7.2656 mL	36.3280 mL
10 mM	0.3633 mL	1.8164 mL	3.6328 mL	18.1640 mL
20 mM	0.1816 mL	0.9082 mL	1.8164 mL	9.0820 mL
50 mM	0.0727 mL	0.3633 mL	0.7266 mL	3.6328 mL
100 mM	0.0363 mL	0.1816 mL	0.3633 mL	1.8164 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc