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Brevianamide F (Alias: Cyclo-L-tryptophyl-L-proline, cyclo-(L-Trp-L-Pro), Cyclo(L-Pro-L-Trp))

Name: Brevianamide F
Brand: TargetMol
SKU: T3208
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T3208 Copy Product Info

Purity: 98.82%

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Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), is a naturally occurring 2,5-diketopiperazine with notable breast cancer resistance protein inhibitory activity.

Brevianamide F

Copy Product Info

😃Good

Catalog No. T3208

Alias Cyclo-L-tryptophyl-L-proline, cyclo-(L-Trp-L-Pro), Cyclo(L-Pro-L-Trp)

Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), is a naturally occurring 2,5-diketopiperazine with notable breast cancer resistance protein inhibitory activity.

Cas No. 38136-70-8

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Pack Size	Price	USA Stock	Global Stock
2 mg	$35	In Stock	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$162	In Stock	In Stock
50 mg	$245	In Stock	In Stock
100 mg	$393	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.82%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Brevianamide F AI Summary

Brevianamide F exhibits activity at Aspergillus fumigatus FtmPT1, determined by HPLC analysis, with a Km value of 55000.0 nM and a Kcat value of 5.57 /s, and a Kcat/Km ratio of 675.0 relative to L-tryptophan. It shows cytotoxicity against human K562, human cisplatin-sensitive A2780, and human cisplatin-resistant A2780 cells with IC50 values greater than 100,000.0 nM after 72 hours as measured by the MTT assay, indicating low potency. In Artemia salina (brine shrimp), it has an LC50 value of 83.7 μg/mL at 28°C after 48 hours. Against human HeLa cells, it has an IC50 value greater than 200,000.0 nM after 72 hours, showing a weak inhibitory effect. It exhibits antibacterial activity against Staphylococcus aureus (MIC 12.6 μg/mL) and Bacillus subtilis (MIC 11.9 μg/mL) but not against Escherichia coli (MIC > 20.0 μg/mL). It has antimycobacterial activity against Mycobacterium bovis BCG (MIC 44170.0 nM) and Mycobacterium tuberculosis BCG (MIC 44100.0 nM). Additionally, it displays antimicrobial activity against Staphylococcus aureus ATCC 25923, with an inhibition zone of 19.0 mm, and Candida albicans ATCC 14053, with an inhibition zone of 25.0 mm..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), is a naturally occurring 2,5-diketopiperazine with notable breast cancer resistance protein inhibitory activity.
Targets&IC50	PI3Kα:4.8 μM (IC50)
Synonyms	Cyclo-L-tryptophyl-L-proline, cyclo-(L-Trp-L-Pro), Cyclo(L-Pro-L-Trp)

Chemical Properties

Molecular Weight	283.33
Formula	C₁₆H₁₇N₃O₂
Cas No.	38136-70-8
Smiles	O=C1N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N2CCC[C@@H]12
Relative Density.	1.37 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (176.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5295 mL	17.6473 mL	35.2945 mL	176.4727 mL
5 mM	0.7059 mL	3.5295 mL	7.0589 mL	35.2945 mL
10 mM	0.3529 mL	1.7647 mL	3.5295 mL	17.6473 mL
20 mM	0.1765 mL	0.8824 mL	1.7647 mL	8.8236 mL
50 mM	0.0706 mL	0.3529 mL	0.7059 mL	3.5295 mL
100 mM	0.0353 mL	0.1765 mL	0.3529 mL	1.7647 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc