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Fenhexamid

Name: Fenhexamid
Brand: TargetMol
SKU: T20237
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20237Cas No. 126833-17-8

Alias Teldor, Elevate

Fenhexamid (Elevate), a sterol biosynthesis inhibitor, shows antifungal activity against the plant pathogenic fungus. Fenhexamid is used for agriculture and is present in measurable amounts in fruits and vegetables.

Fenhexamid

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Purity: 99.56%

Catalog No. T20237Alias Teldor, ElevateCas No. 126833-17-8

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$29	In Stock	In Stock
100 mg	$53	In Stock	In Stock
500 mg	$128	In Stock	In Stock
1 g	$188	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.56%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Fenhexamid AI Summary

Fenhexamid exhibits broad-spectrum antifungal activity against various fungal pathogens, including Botrytis cinerea, Monilinia laxa, Botryotinia fuckeliana, Oculimacula yallundae, and Oculimacula acuformis. It inhibits mycelial growth and germ tube elongation in Botrytis cinerea with EC50 values ranging from 0.2 to 5.0 μg/mL, and shows enhanced activity against fenhexamid-sensitive strains with EC50 values below 0.1 μg/mL. However, its efficacy is limited against highly fenhexamid-resistant strains, where EC50 values exceed 10.0 μg/mL. Additionally, Fenhexamid demonstrates fungicidal activity against Monilinia laxa with varying levels of efficacy, as reflected in EC50 values from 0.1 to 11.1 μg/mL and mycelial colony reductions ranging from 49.0 to 60.0 mm. The compound also exhibits bioactivity in several signaling pathways, including the farnesoid X receptor (FXR) with a potency of 0.7 nM, the antioxidant response element (ARE) signaling pathway with potencies of 30637.9 nM and 61130.6 nM, and the human pregnane X receptor (PXR) signaling pathway with a potency of 50118.7 nM. Additionally, it has shown preventive antifungal effects on gray mold (Botryotinia fuckeliana) in cucumber seedlings, with an EC50 value of 2.13 μg/mL when sprayed before inoculation. Fenhexamid also demonstrates fungicidal activity against Botryotinia fuckeliana in strawberry fruit, showing both curative and protective effects by significantly reducing disease incidence and lesion diameter. Lastly, the compound exhibits selective activity against Oculimacula yallundae and Oculimacula acuformis, effectively inhibiting their growth and overcoming resistance in sterol 14alpha-demethylation inhibitor-resistant strains. Overall, Fenhexamid displays promising potential as a fungicide with selective and potent bioactivity against numerous fungal pathogens..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Fenhexamid (Elevate), a sterol biosynthesis inhibitor, shows antifungal activity against the plant pathogenic fungus. Fenhexamid is used for agriculture and is present in measurable amounts in fruits and vegetables.
Synonyms	Teldor, Elevate

Chemical Properties

Molecular Weight	302.20
Formula	C₁₄H₁₇Cl₂NO₂
Cas No.	126833-17-8
Smiles	CC1(CCCCC1)C(=O)Nc1ccc(O)c(Cl)c1Cl
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (132.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3091 mL	16.5453 mL	33.0907 mL	165.4533 mL
5 mM	0.6618 mL	3.3091 mL	6.6181 mL	33.0907 mL
10 mM	0.3309 mL	1.6545 mL	3.3091 mL	16.5453 mL
20 mM	0.1655 mL	0.8273 mL	1.6545 mL	8.2727 mL
50 mM	0.0662 mL	0.3309 mL	0.6618 mL	3.3091 mL
100 mM	0.0331 mL	0.1655 mL	0.3309 mL	1.6545 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc