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LAZABEMIDE

Name: LAZABEMIDE
Brand: TargetMol
SKU: T5470
Rating: 4.5 (1 reviews)

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Catalog No. T5470Cas No. 103878-84-8

Alias Ro 19-6327

Lazabemide (Ro 19-6327) is a selective and reversible monoamine oxidase B (MAO-B) inhibitor with IC50 values of 0.03 μM for MAO-B and >100 μM for MAO-A.

LAZABEMIDE

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Catalog No. T5470Alias Ro 19-6327Cas No. 103878-84-8

Lazabemide (Ro 19-6327) is a selective and reversible monoamine oxidase B (MAO-B) inhibitor with IC50 values of 0.03 μM for MAO-B and >100 μM for MAO-A.

Pack Size	Price	Availability
10 mg	$50	6-8 weeks
25 mg	$108	6-8 weeks
50 mg	$182	6-8 weeks
100 mg	$273	6-8 weeks
1 mL x 10 mM (in DMSO)	$47	6-8 weeks

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Product Introduction

Bioactivity

Description	Lazabemide (Ro 19-6327) is a selective and reversible monoamine oxidase B (MAO-B) inhibitor with IC50 values of 0.03 μM for MAO-B and >100 μM for MAO-A.
Targets&IC50	MAO-B:30 nM
In vitro	LAZABEMIDE is selective, high-affinity ligands for enzymes.?KD and Bmax values for 3H-Ro 41 1049 in rat cerebral cortex were 10.7 nM and 7.38 pmol/mg protein, respectively, and for 3H-Ro 19 6327 were 18.4 nM and 3.45 pmol/mg protein, respectively.?In accordance with their potencies as enzyme inhibitors, binding to MAO-A and MAO-B was competitively inhibited by clorgyline (IC50 = 1.4 nM) and L-deprenyl (selegiline;?IC50 = 8.0 nM), respectively[1].
In vivo	Lazabemide is a reversible inhibitor of monoamine oxidase B (MAO-B) with IC50 values of 0.48 and 1.5 μM measured in platelets of human subjects ages 19-36 and 60-78, respectively[2].
Synonyms	Ro 19-6327

Chemical Properties

Molecular Weight	199.64
Formula	C₈H₁₀ClN₃O
Cas No.	103878-84-8
Relative Density.	1.286g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 34 mg/mL (170.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0090 mL	25.0451 mL	50.0902 mL	250.4508 mL
5 mM	1.0018 mL	5.0090 mL	10.0180 mL	50.0902 mL
10 mM	0.5009 mL	2.5045 mL	5.0090 mL	25.0451 mL
20 mM	0.2505 mL	1.2523 mL	2.5045 mL	12.5225 mL
50 mM	0.1002 mL	0.5009 mL	1.0018 mL	5.0090 mL
100 mM	0.0501 mL	0.2505 mL	0.5009 mL	2.5045 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc