Cyclic ADP-ribose ammonium

Name: Cyclic ADP-ribose ammonium
Brand: TargetMol
SKU: T37687
Rating: 4.5 (1 reviews)

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Catalog No. T37687

Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent calcium mobilization second messenger synthesized from NAD+ by ADP-ribosyl cyclase. It raises cytosolic calcium levels through Ryanodine receptor-mediated release from the endoplasmic reticulum and facilitates extracellular influx via TRPM2 channels [1][2][3].

Cyclic ADP-ribose ammonium

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Catalog No. T37687

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Product Introduction

Bioactivity

Description	Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent calcium mobilization second messenger synthesized from NAD+ by ADP-ribosyl cyclase. It raises cytosolic calcium levels through Ryanodine receptor-mediated release from the endoplasmic reticulum and facilitates extracellular influx via TRPM2 channels [1][2][3].
In vitro	cADPR (20 nM) prompts a significant, rapid Ca2+ release in sea urchin egg homogenates [1]. cADPR (100 μM; 10 min) causes a sustained increase in intracellular calcium concentration in 64% of cultured astrocytes [4]. cADPR (100 μM) and heat (35-38.5 ℃) stimulate oxytocin OT release from isolated hypothalami of male mice in culture [5].
In vivo	cADPR (100 μM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice[5].

Chemical Properties

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