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Bergaptol

Name: Bergaptol
Brand: TargetMol
SKU: T2S1434
Price: 49 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2S1434Cas No. 486-60-2

Alias 5-Hydroxypsoralen, 5-Hydroxyfuranocoumarin, 4-Hydroxybergapten

1. Bergaptol (4-Hydroxybergapten) shows very good radical scavenging activity. 2. Bergaptol is a potent inhibitor of debenzylation activity of CYP3A4 enzyme.

Bergaptol

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Purity: 99.61%

Catalog No. T2S1434Alias 5-Hydroxypsoralen, 5-Hydroxyfuranocoumarin, 4-HydroxybergaptenCas No. 486-60-2

1. Bergaptol (4-Hydroxybergapten) shows very good radical scavenging activity. 2. Bergaptol is a potent inhibitor of debenzylation activity of CYP3A4 enzyme.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$29	In Stock	In Stock
25 mg	$49	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.61%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bergaptol AI Summary

Bergaptol exhibits diverse biological activities, including significant ABTS and DPPH radical scavenging activity at 200 ppm and 800 ppm concentrations, demonstrating potential antioxidant properties with activities ranging from 29.7% to 91.1%. It also shows inhibitory activity against CYP3A4 with an IC50 of 24920.0 nM and nearly full inhibition at 0.1 mM concentration. Despite its low bioactivity in anticancer and anticorpulence assays with IC50 values above 500,000.0 nM, Bergaptol inhibits multiple enzymes and pathways, affecting targets such as Tau fibril formation, ALDH1A1, IMPase, L3MBTL1, HPGD, ROR gamma, and others. It also acts as an inducer of DNA re-replication and a potential antagonist for EPAC1. Furthermore, it exhibits mechanism-based inhibition of CYP2A6 with a Ki of 11600.0 nM and Kinact of 0.02 min-1. Bergaptol enhances Vinblastine uptake in Caco-2 cells via TP Transporter and demonstrates inhibitory action against soybean LOX with an IC50 of 41500.0 nM and significant antioxidant effects in various assays. Lastly, it shows antimycobacterial activity against Mycobacterium tuberculosis H37Rv with a MIC of 100.0 µg/mL, indicating its broad-spectrum bioactivity across multiple targets and biological pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Bergaptol (4-Hydroxybergapten) shows very good radical scavenging activity. 2. Bergaptol is a potent inhibitor of debenzylation activity of CYP3A4 enzyme.
Targets&IC50	CYP3A4:24.92 μM
Synonyms	5-Hydroxypsoralen, 5-Hydroxyfuranocoumarin, 4-Hydroxybergapten

Chemical Properties

Molecular Weight	202.16
Formula	C₁₁H₆O₄
Cas No.	486-60-2
Smiles	Oc1c2ccoc2cc2oc(=O)ccc12
Relative Density.	1.526g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 145 mg/mL (717.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9466 mL	24.7329 mL	49.4658 mL	247.3288 mL
5 mM	0.9893 mL	4.9466 mL	9.8932 mL	49.4658 mL
10 mM	0.4947 mL	2.4733 mL	4.9466 mL	24.7329 mL
20 mM	0.2473 mL	1.2366 mL	2.4733 mL	12.3664 mL
50 mM	0.0989 mL	0.4947 mL	0.9893 mL	4.9466 mL
100 mM	0.0495 mL	0.2473 mL	0.4947 mL	2.4733 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc